# Collagen type I alpha 2 chain

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5013311](https://www.wikidata.org/wiki/Q5013311)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Collagen,_type_I,_alpha_2)  
**Source**: https://4ort.xyz/entity/collagen-type-i-alpha-2-chain


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2095222)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08123)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
6. [Three arginine to cysteine substitutions in the pro-alpha (I)-collagen chain cause Ehlers-Danlos syndrome with a propensity to arterial rupture in early adulthood](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
7. [Defective C-propeptides of the proalpha2(I) chain of type I procollagen impede molecular assembly and result in osteogenesis imperfecta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
8. [Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
9. [Genetic analysis of structural elastic fiber and collagen genes in familial adolescent idiopathic scoliosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
11. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
12. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
13. [MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
14. [Genetic analysis of structural elastic fiber and collagen genes in familial adolescent idiopathic scoliosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
16. [Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
17. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
18. [Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
19. [Proteomics characterization of extracellular space components in the human aorta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
20. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
21. [Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
22. [Proteomics characterization of extracellular space components in the human aorta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
23. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
24. [Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
25. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
26. [Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
27. [Protein profile of exosomes from trabecular meshwork cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
28. [Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
29. [Cloning a cDNA for the pro-alpha 2 chain of human type I collagen](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
30. [Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
31. [Defective C-propeptides of the proalpha2(I) chain of type I procollagen impede molecular assembly and result in osteogenesis imperfecta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
32. [MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
33. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08123&geneProductId=UniProtKB:P08123)
34. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
35. [Cloning a cDNA for the pro-alpha 2 chain of human type I collagen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
36. [Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
37. [Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
38. [Protein profile of exosomes from trabecular meshwork cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
39. [Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
40. [Expression of Type I Collagen Pro-α2 Chain mRNA in Adult Human Permanent Teeth as Revealed by in situ Hybridization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
41. [Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
42. [Association of gene polymorphisms with blood pressure and the prevalence of hypertension in community-dwelling Japanese individuals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08123)
43. Ensembl Release 99
44. Identifiers.org