# collagen type I alpha 1 chain

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5145884](https://www.wikidata.org/wiki/Q5145884)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Collagen,_type_I,_alpha_1)  
**Source**: https://4ort.xyz/entity/collagen-type-i-alpha-1-chain


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P02452)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
5. [Three arginine to cysteine substitutions in the pro-alpha (I)-collagen chain cause Ehlers-Danlos syndrome with a propensity to arterial rupture in early adulthood](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
6. [Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
8. [TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
9. [Defective C-propeptides of the proalpha2(I) chain of type I procollagen impede molecular assembly and result in osteogenesis imperfecta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
10. [Zinc induces structural reorganization of gelatin binding domain from human fibronectin and affects collagen binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
11. [Structural and functional analysis of the fibronectin-binding protein FNE from Streptococcus equi spp. equi](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
12. [Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
13. [MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
15. [Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
16. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
17. [Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
18. [Proteomics characterization of extracellular space components in the human aorta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
19. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
20. [Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
21. [Proteomics characterization of extracellular space components in the human aorta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
22. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
23. [Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
24. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
25. [Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
26. [Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
27. [Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
28. [Gene targeting in stem cells from individuals with osteogenesis imperfecta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
29. [RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
30. [MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
31. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
32. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
33. [RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
34. [Gene targeting in stem cells from individuals with osteogenesis imperfecta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
35. [Nonmuscle myosin-dependent synthesis of type I collagen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
36. [Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
37. [Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
38. [Reduced type I collagen utilization: a pathogenic mechanism in COL5A1 haplo-insufficient Ehlers-Danlos syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
39. [Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
40. [Abnormal dentin structure in two novel gene mutations [COL1A1, Arg134Cys] and [ADAMTS2, Trp795-to-ter] causing rare type I collagen disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
41. [Single-nucleotide polymorphisms in the COL1A1 regulatory regions are associated with otosclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
42. [The COL1A1 gene and high myopia susceptibility in Japanese](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
43. [Prenatal cortical hyperostosis with COL1A1 gene mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
44. [Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of type I procollagen in lethal osteogenesis imperfecta. The conformational strain on the triple helix introduced by a glycine substitution can be transmitted along the helix](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
45. [Homology-mediated recombination between type I collagen gene exons results in an internal tandem duplication and lethal osteogenesis imperfecta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
46. [Three arginine to cysteine substitutions in the pro-alpha (I)-collagen chain cause Ehlers-Danlos syndrome with a propensity to arterial rupture in early adulthood](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452)
47. [Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of type I procollagen in lethal osteogenesis imperfecta. The conformational strain on the triple helix introduced by a glycine substitution can be transmitted along the helix](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
48. [Homology-mediated recombination between type I collagen gene exons results in an internal tandem duplication and lethal osteogenesis imperfecta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452)
49. Ensembl Release 99
50. Identifiers.org