# Coagulation factor II, thrombin

> mammalian protein found in Homo sapiens

**Wikidata**: [Q409166](https://www.wikidata.org/wiki/Q409166)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Thrombin)  
**Source**: https://4ort.xyz/entity/coagulation-factor-ii-thrombin


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL539697)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1166)
5. [Nuovo soggettario](https://thes.bncf.firenze.sbn.it/termine.php?id=1272)
6. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P00734)
7. Nuovo soggettario
8. Q20641742
9. Freebase Data Dumps. 2013
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
11. [Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
12. [Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
13. [Isolation of the thrombospondin membrane receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
14. [Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
15. [Mechanism of Inhibition of Activated Protein C by Protein C Inhibitor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
16. [Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
17. [Two different proteins that compete for binding to thrombin have opposite kinetic and thermodynamic profiles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
18. [Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
19. [Localization of protease nexin-1 on the fibroblast extracellular matrix](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00734&geneProductId=UniProtKB:P00734)
21. [Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00734&geneProductId=UniProtKB:P00734)
22. [Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00734&geneProductId=UniProtKB:P00734)
23. [Proteolysis of human thrombin generates novel host defense peptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
24. [Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
25. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00734&geneProductId=UniProtKB:P00734)
26. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00734&geneProductId=UniProtKB:P00734)
27. [Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00734&geneProductId=UniProtKB:P00734)
28. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00734&geneProductId=UniProtKB:P00734)
29. [Proteolysis of human thrombin generates novel host defense peptides](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00734&geneProductId=UniProtKB:P00734)
30. [Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00734&geneProductId=UniProtKB:P00734)
31. [Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
32. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
33. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
34. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
35. [Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
36. [NOX5 variants are functionally active in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
37. [Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
38. [Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
39. [Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
40. [A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
41. [Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
42. [Reciprocal Modulation of Astrocyte Stellation by Thrombin and Protease Nexin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
43. [Protein kinase C regulates pleckstrin by phosphorylation of sites adjacent to the N-terminal pleckstrin homology domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
44. [Inhibition of ADP-induced Platelet Responses by Covalent Modification of Aggregin, a Putative ADP Receptor, by 8-(4-Bromo-2,3-dioxobutylthio)ADP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
45. [Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
46. [Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
47. [Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00734)
48. YSO-Wikidata mapping project. 2024
49. Identifiers.org
50. National Library of Israel