# coagulation factor II thrombin receptor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21106737](https://www.wikidata.org/wiki/Q21106737)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Proteinase-activated_receptor_1)  
**Source**: https://4ort.xyz/entity/coagulation-factor-ii-thrombin-receptor


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2103856)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P25116)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116)
7. [Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116)
8. [Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116)
9. [Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116)
10. [Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
12. [ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
13. [Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
14. [Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
15. [Factor X/Xa Elicits Protective Signaling Responses in Endothelial Cells Directly via PAR-2 and Indirectly via Endothelial Protein C Receptor-dependent Recruitment of PAR-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
16. [A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
17. [Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
18. [Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
20. [Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
21. [Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
22. [Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
23. [Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
24. [Thrombin receptor overexpression in malignant and physiological invasion processes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
25. [Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
26. [Neutrophil Proteinase 3 Acts on Protease-Activated Receptor-2 to Enhance Vascular Endothelial Cell Barrier Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116)
27. Ensembl Release 99
28. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
29. UMLS 2023