# clavulanic acid

> Β-lactam molecule used as β-lactamase inhibitor to overcome antibiotic resistance in bacteria

**Wikidata**: [Q415709](https://www.wikidata.org/wiki/Q415709)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Clavulanic_acid)  
**Source**: https://4ort.xyz/entity/clavulanic-acid


## References

1. clavulanic acid. Global Substance Registration System
2. [CAS Common Chemistry](https://commonchemistry.cas.org/detail?cas_rn=58001-44-8)
3. CLAVULANIC ACID. PubChem
4. ChEBI release 2020-09-01
5. Clavulanate. DrugBank. 2015
6. Medical Subject Headings
7. CLAVULANIC ACID. ChEMBL
8. IUPHAR/BPS Guide to PHARMACOLOGY
9. 2XH9. Protein Data Bank
10. 2XF3. Protein Data Bank
11. 2XFS. Protein Data Bank
12. 2JAP. Protein Data Bank
13. Freebase Data Dumps. 2013
14. clavulanic acid. ChemSpider
15. clavulanic acid. ChEBI
16. ChEBI release 2019-10-02
17. The origin of the β-lactam carbons of clavulanic acid
18. Evidence that arginine is a later metabolic intermediate than ornithine in the biosynthesis of clavulanic acid by Streptomyces clavuligerus
19. Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analogue
20. Biosynthesis of clavulanic acid: origin of the C3 unit
21. Biosynthesis of clavulanic acid: origin of the C5 unit
22. The stereochemical fate of (2RS,5R)- and (2RS,5S)-[5-3H]ornithine in clavulanic acid biosynthesis
23. Clavulanic acid biosynthesis: the stereochemical course of β-lactam formation from chiral glycerol
24. The role of molecular oxygen in clavulanic acid biosynthesis: evidence for a bacterial oxidative deamination
25. Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis
26. A novel finding that Streptomyces clavuligerus can produce the antibiotic clavulanic acid using olive oil as a sole carbon source.
27. Induction of Holomycin Production and Complex Metabolic Changes by the argR Mutation in Streptomyces clavuligerus NP1
28. Data set of in silico simulation for the production of clavulanic acid and cephamycin C by Streptomyces clavuligerus using a genome scale metabolic model
29. Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus
30. A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications
31. An improved HPLC-DAD method for clavulanic acid quantification in fermentation broths of Streptomyces clavuligerus
32. Coordination of glycerol utilization and clavulanic acid biosynthesis to improve clavulanic acid production in Streptomyces clavuligerus
33. Homologous expression of lysA encoding diaminopimelic acid (DAP) decarboxylase reveals increased antibiotic production in Streptomyces clavuligerus
34. The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene
35. Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways
36. A pathway‐specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus
37. Clavulanic acid production estimation based on color and structural features of Streptomyces clavuligerus bacteria using self-organizing map and genetic algorithm.
38. Role of the cmcH–ccaR intergenic region and ccaR overexpression in cephamycin C biosynthesis in Streptomyces clavuligerus
39. Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus
40. Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus
41. Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus
42. Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus
43. Improvement of clavulanic acid production in Streptomyces clavuligerus by genetic manipulation of structural biosynthesis genes
44. A statistical approach using L(25) orthogonal array method to study fermentative production of clavulanic acid by Streptomyces clavuligerus MTCC 1142.
45. Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus
46. 5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus.
47. Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064
48. In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus
49. Effect of water activity on production of beta-lactam antibiotics by Streptomyces clavuligerus in submerged culture
50. 5S Clavam Biosynthesis Is Controlled by an Atypical Two-Component Regulatory System in Streptomyces clavuligerus