# Circadian locomotor output cycles kaput

> mammalian protein found in Mus musculus

**Wikidata**: [Q14908776](https://www.wikidata.org/wiki/Q14908776)  
**Source**: https://4ort.xyz/entity/circadian-locomotor-output-cycles-kaput


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O08785)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
5. [Biochemical analysis of the canonical model for the mammalian circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
6. [Biological clock in total darkness: the Clock/MOP3 circadian system of the blind subterranean mole rat](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
7. [Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
8. [Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
9. [A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
10. [Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
11. [CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
12. [Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
13. [Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
14. [Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
15. [Metastasis-associated protein 1 is an integral component of the circadian molecular machinery](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
16. [A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
17. [Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
18. [cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
19. [The histone methyltransferase MLL1 permits the oscillation of circadian gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
20. [p53 regulates Period2 expression and the circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
21. [CIPC is a mammalian circadian clock protein without invertebrate homologues](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
22. [The polycomb group protein EZH2 is required for mammalian circadian clock function](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
23. [Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
24. [Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
25. [Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
26. [CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
27. [A molecular mechanism for circadian clock negative feedback](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
28. [Core circadian protein CLOCK is a positive regulator of NF-κB–mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
29. [Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
30. [SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
31. [The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
32. [SIRT1 regulates circadian clock gene expression through PER2 deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
33. [Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
34. [A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
35. [Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
36. [Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
37. [Rapid activation of CLOCK by Ca2+-dependent protein kinase C mediates resetting of the mammalian circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
38. [Imaging of heme/hemeproteins in nucleus of the living cells expressing heme‐binding nuclear receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
39. [The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
40. [Machine Learning Helps Identify CHRONO as a Circadian Clock Component](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
41. [Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
42. [Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
43. [JNK regulates the photic response of the mammalian circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
44. [Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
45. [CLOCK-mediated acetylation of BMAL1 controls circadian function](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
46. [CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
47. [Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
48. [Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
49. [Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)
50. [The BMAL1 C terminus regulates the circadian transcription feedback loop.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08785&geneProductId=UniProtKB:O08785)