# Chromatin licensing and DNA replication factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5205770](https://www.wikidata.org/wiki/Q5205770)  
**Source**: https://4ort.xyz/entity/chromatin-licensing-and-dna-replication-factor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9H211)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211)
5. [Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
6. [Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
7. [USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
8. [A WD-Repeat Protein Stabilizes ORC Binding to Chromatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
9. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
10. [Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
11. [Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
12. [Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
13. [Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
14. [Characterization and Structure Determination of the Cdt1 Binding Domain of Human Minichromosome Maintenance (Mcm) 6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
15. [Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
16. [Inhibition of eukaryotic DNA replication by geminin binding to Cdt1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
17. [The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
18. [Self-assembling protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
19. [Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
20. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
21. [JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
24. [Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211)
25. [Inhibition of eukaryotic DNA replication by geminin binding to Cdt1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211)
26. [The histone demethylase LSD1/KDM1A promotes the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211)
27. [Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211)
28. [The histone demethylase LSD1/KDM1A promotes the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211)
29. [The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211)
30. Ensembl Release 99
31. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)