# Christian B. Anfinsen

> American biochemist (1916–1995)

**Wikidata**: [Q102278](https://www.wikidata.org/wiki/Q102278)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Christian_B._Anfinsen)  
**Source**: https://4ort.xyz/entity/christian-b-anfinsen

## Summary
Christian B. Anfinsen was an American biochemist (1916–1995) renowned for his groundbreaking work on protein folding and the thermodynamic hypothesis, which posits that the three-dimensional structure of a protein is determined solely by its amino acid sequence. His research earned him the Nobel Prize in Chemistry in 1972, and he is best known for Anfinsen's dogma, a foundational principle in molecular biology.

## Biography
- **Born**: March 26, 1916
- **Nationality**: American
- **Education**:
  - Swarthmore College (Bachelor's degree)
  - University of Pennsylvania (Ph.D. in Biochemistry)
  - Harvard Medical School (Postdoctoral research)
- **Known for**: Pioneering work on protein folding and the thermodynamic hypothesis
- **Employer(s)**:
  - National Institutes of Health (NIH)
  - Harvard Medical School
  - Johns Hopkins University
- **Field(s)**: Biochemistry, Biophysics

## Contributions
Christian B. Anfinsen made significant contributions to the field of biochemistry, particularly in the study of protein folding. His most notable work includes:
- **Anfinsen's Dogma (1961)**: Demonstrated that the three-dimensional structure of a protein is determined by its amino acid sequence, a foundational principle in molecular biology.
- **Ribonuclease Refolding Experiments**: Showed that denatured ribonuclease could refold into its native structure without external factors, supporting the thermodynamic hypothesis.
- **Nobel Prize in Chemistry (1972)**: Awarded for his work on ribonuclease, particularly his contributions to the understanding of the connection between the amino acid sequence and the biologically active conformation of proteins.
- **Publications**: Authored numerous influential papers and books, including *The Molecular Basis of Evolution* (1959), which explored the evolutionary implications of protein structure.

## FAQs
### What is Anfinsen's dogma?
Anfinsen's dogma is the hypothesis that the three-dimensional structure of a protein is determined solely by its amino acid sequence. This principle is fundamental to understanding protein folding and function.

### Where did Christian B. Anfinsen work?
Christian B. Anfinsen worked at several prestigious institutions, including the National Institutes of Health (NIH), Harvard Medical School, and Johns Hopkins University.

### What awards did Christian B. Anfinsen receive?
Christian B. Anfinsen received numerous awards, including the Nobel Prize in Chemistry in 1972, the Guggenheim Fellowship, and an honorary doctorate from the University of Las Palmas, Gran Canaria. He was also a Fellow of the American Academy of Arts and Sciences.

### What is Christian B. Anfinsen known for?
Christian B. Anfinsen is best known for his work on protein folding and the thermodynamic hypothesis, which earned him the Nobel Prize in Chemistry. His research on ribonuclease refolding experiments was particularly influential.

### What is the significance of Anfinsen's work?
Anfinsen's work on protein folding has had a profound impact on molecular biology and biochemistry. His findings have influenced the development of drugs, diagnostic tools, and therapeutic interventions by revealing the chemical mechanisms underlying diseases.

## Why They Matter
Christian B. Anfinsen's work on protein folding and the thermodynamic hypothesis has had a lasting impact on the fields of biochemistry and molecular biology. His research provided a fundamental understanding of how proteins achieve their three-dimensional structures, which is crucial for their biological functions. This knowledge has been instrumental in the development of life-saving drugs, diagnostic tools, and therapeutic interventions. Anfinsen's contributions have also influenced the study of genetic expression, protein function, and metabolic pathways, making him a pivotal figure in the advancement of biochemistry.

## Notable For
- **Nobel Prize in Chemistry (1972)**: Awarded for his work on ribonuclease and the thermodynamic hypothesis.
- **Anfinsen's Dogma**: A foundational principle in molecular biology that the three-dimensional structure of a protein is determined by its amino acid sequence.
- **Ribonuclease Refolding Experiments**: Demonstrated that denatured ribonuclease could refold into its native structure without external factors.
- **Guggenheim Fellowship**: Recognized for his contributions to biochemistry.
- **Honorary Doctorate**: Received from the University of Las Palmas, Gran Canaria.
- **Fellow of the American Academy of Arts and Sciences**: Honored for his scientific achievements.
- **Member of the National Academy of Sciences**: Recognized for his contributions to biochemistry.
- **Member of the Pontifical Academy of Sciences**: Honored for his scientific work.
- **Member of the American Philosophical Society**: Recognized for his contributions to science.

## Body
### Early Life and Education
Christian B. Anfinsen was born on March 26, 1916. He pursued his undergraduate studies at Swarthmore College, where he earned a Bachelor's degree. He then attended the University of Pennsylvania, where he obtained a Ph.D. in Biochemistry. Anfinsen conducted postdoctoral research at Harvard Medical School, furthering his expertise in biochemistry and biophysics.

### Career and Research
Anfinsen's career was marked by significant contributions to the field of biochemistry. He worked at several prestigious institutions, including the National Institutes of Health (NIH), Harvard Medical School, and Johns Hopkins University. His research focused on protein folding and the thermodynamic hypothesis, which posits that the three-dimensional structure of a protein is determined solely by its amino acid sequence.

### Anfinsen's Dogma
One of Anfinsen's most notable contributions is Anfinsen's dogma, a hypothesis that has become a foundational principle in molecular biology. This principle states that the three-dimensional structure of a protein is determined by its amino acid sequence. Anfinsen's work on ribonuclease refolding experiments demonstrated that denatured ribonuclease could refold into its native structure without external factors, supporting the thermodynamic hypothesis.

### Awards and Recognition
Anfinsen's groundbreaking work earned him numerous awards and honors. In 1972, he was awarded the Nobel Prize in Chemistry for his work on ribonuclease and the thermodynamic hypothesis. He also received the Guggenheim Fellowship and an honorary doctorate from the University of Las Palmas, Gran Canaria. Anfinsen was a Fellow of the American Academy of Arts and Sciences and a member of the National Academy of Sciences, the Pontifical Academy of Sciences, and the American Philosophical Society.

### Publications and Influence
Anfinsen authored numerous influential papers and books, including *The Molecular Basis of Evolution* (1959), which explored the evolutionary implications of protein structure. His research has had a profound impact on the fields of biochemistry and molecular biology, influencing the development of drugs, diagnostic tools, and therapeutic interventions. His work continues to be a cornerstone in the study of protein folding and function.

### Legacy
Christian B. Anfinsen's legacy in biochemistry is marked by his pioneering work on protein folding and the thermodynamic hypothesis. His contributions have provided a fundamental understanding of how proteins achieve their three-dimensional structures, which is crucial for their biological functions. This knowledge has been instrumental in the development of life-saving drugs, diagnostic tools, and therapeutic interventions. Anfinsen's work has also influenced the study of genetic expression, protein function, and metabolic pathways, making him a pivotal figure in the advancement of biochemistry.

## References

1. [Christian B. Anfinsen, Nobel Winner in Chemistry, Dies at 79. The New York Times. 1995](https://www.nytimes.com/1995/05/16/obituaries/christian-b-anfinsen-nobel-winner-in-chemistry-dies-at-79.html)
2. NNDB
3. Encyclopædia Britannica Online
4. Encyclopedia.com
5. BnF authorities
6. Find a Grave
7. Guggenheim Fellows database
8. [The Nobel Prize in Chemistry 1972. Nobel Foundation](https://www.nobelprize.org/prizes/chemistry/1972/summary/)
9. [Table showing prize amounts. Nobel Foundation. 2019](https://www.nobelprize.org/uploads/2019/04/prize-amounts-2020.pdf)
10. International Standard Name Identifier
11. Virtual International Authority File
12. CiNii Research
13. www.pas.va
14. SNAC
15. Solomon R. Guggenheim Museum
16. Brockhaus Enzyklopädie
17. Proleksis Encyclopedia
18. Croatian Encyclopedia
19. Two Subsites in the Binding Domain of the Acetylcholine Receptor: An Aromatic Subsite and a Proline Subsite. JSTOR
20. [No Assembly Required](https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1002/j.2326-1951.1996.tb03226.x)
21. Base biographique
22. Freebase Data Dumps. 2013
23. Catalogo of the National Library of India