# Cholinergic receptor, nicotinic, alpha polypeptide 7

> mammalian protein found in Mus musculus

**Wikidata**: [Q21111177](https://www.wikidata.org/wiki/Q21111177)  
**Source**: https://4ort.xyz/entity/cholinergic-receptor-nicotinic-alpha-polypeptide-7


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49582)
3. Q20641742
4. [Swiss-Prot](http://www.uniprot.org/uniprot/P36544.txt?164)
5. [A role for LYNX2 in anxiety-related behavior](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
8. [Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
9. [Linkage of strain-specific nicotinic receptor alpha 7 subunit restriction fragment length polymorphisms with levels of alpha-bungarotoxin binding in brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
10. [Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
11. [Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
12. [Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
13. [Presynaptic type III neuregulin1-ErbB signaling targets {alpha}7 nicotinic acetylcholine receptors to axons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
14. [Nicotinic receptors regulate B lymphocyte activation and immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
15. [Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
16. [Dystrophin stabilizes alpha 3- but not alpha 7-containing nicotinic acetylcholine receptor subtypes at the postsynaptic apparatus in the mouse superior cervical ganglion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
17. [Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
18. [Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
19. [Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
20. [Altered baroreflex responses in alpha7 deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
21. [Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
22. [Regulation of NMDA receptor trafficking by amyloid-beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
23. [Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
24. [Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
25. [Long-term effects of chronic nicotine exposure on brain nicotinic receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
26. [The role of nicotinic acetylcholine receptors in lymphocyte development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
27. [Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
28. [A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
29. [Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
30. [alpha7 Nicotinic acetylcholine receptor knockout selectively enhances ethanol-, but not beta-amyloid-induced neurotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
31. [Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
32. [Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
33. [Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
34. [Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
35. [Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
36. [Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
37. [Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
38. [Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
39. [Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
40. [Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
41. [Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
42. [Activation of nicotinic α7 acetylcholine receptor enhances long term potentation in wild type mice but not in APPswe/PS1ΔE9 mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582)
43. ensembl Release 106