# Cholinergic receptor nicotinic alpha 7 subunit

> mammalian protein found in Homo sapiens

**Wikidata**: [Q22676780](https://www.wikidata.org/wiki/Q22676780)  
**Source**: https://4ort.xyz/entity/cholinergic-receptor-nicotinic-alpha-7-subunit-q22676780


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2151437)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2151572)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P36544)
6. Q20641742
7. [Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
8. [Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P36544)
9. [Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P36544)
10. [The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P36544)
11. [Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P36544)
12. [beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
13. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P36544)
14. [Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
16. [Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
18. [Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
19. [Functional interaction between Lypd6 and nicotinic acetylcholine receptors.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
20. [Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
21. [Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer's disease pathogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
22. [Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
23. [PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
24. [The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
25. [Non-neuronal nicotinic alpha 7 receptor, a new endothelial target for revascularization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
26. [Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
27. [A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
28. [Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
29. [Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
30. [Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
31. [beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P36544)
32. [A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P36544)
33. [Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36544)
34. Ensembl Release 99
35. Transporter Classification database