# checkpoint kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5011104](https://www.wikidata.org/wiki/Q5011104)  
**Source**: https://4ort.xyz/entity/checkpoint-kinase-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O96017)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
6. [Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
7. [Linkage of ATM to cell cycle regulation by the Chk2 protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017)
9. [Chk2 activates E2F-1 in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017)
10. [Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange](http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017)
11. [Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
12. [The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
13. [Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
14. [PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
15. [Per3, a circadian gene, is required for Chk2 activation in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
16. [ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
17. [Systematic identification of molecular links between core and candidate genes in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
18. [Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
19. [Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
20. [Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
21. [Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
22. [A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
23. [Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
24. [CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11p110](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
25. [Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
26. [The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
27. [TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
28. [Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
29. [Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
30. [The E3 ligase RNF8 regulates KU80 removal and NHEJ repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
31. [Linkage of ATM to cell cycle regulation by the Chk2 protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
32. [Chk2 activates E2F-1 in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
33. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
34. [Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
35. [Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta](http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017)
36. [Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
37. [A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
38. [PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
39. [Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
40. [The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
41. [The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
42. [Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017)
43. Ensembl Release 99
44. Identifiers.org
45. UMLS 2023