# Checkpoint kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109168](https://www.wikidata.org/wiki/Q21109168)  
**Source**: https://4ort.xyz/entity/checkpoint-kinase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O14757)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
5. [Phosphorylation at serine 331 is required for Aurora B activation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
6. [The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
7. [Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
8. [Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
9. [The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
10. [Coupling of human circadian and cell cycles by the timeless protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
11. [Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
12. [Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
13. [BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
14. [Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
15. [14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
16. [Menin stimulates homology-directed DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
17. [ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
18. [Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
19. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14757&geneProductId=UniProtKB:O14757)
21. [Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14757&geneProductId=UniProtKB:O14757)
22. [Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
23. [hHR23A is required to control the basal turnover of Chk1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
25. [Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
26. [Atm-dependent interactions of a mammalian Chk1 homolog with meiotic chromosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
27. [Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
28. [DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14757&geneProductId=UniProtKB:O14757)
29. [Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14757&geneProductId=UniProtKB:O14757)
30. [hHR23A is required to control the basal turnover of Chk1](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14757&geneProductId=UniProtKB:O14757)
31. [Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14757&geneProductId=UniProtKB:O14757)
32. [Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
33. [DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
34. [Expression of the Bcl-2 protein BAD promotes prostate cancer growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
35. [The Identification of a Novel Gene, MAPO2, That Is Involved in the Induction of Apoptosis Triggered by O6-Methylguanine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757)
36. Ensembl Release 99
37. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
38. UMLS 2023