# Cell division cycle 37, HSP90 cochaperone

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173027](https://www.wikidata.org/wiki/Q21173027)  
**Source**: https://4ort.xyz/entity/cell-division-cycle-37-hsp90-cochaperone


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q16543)
3. Q20641742
4. [Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16543&geneProductId=UniProtKB:Q16543)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
6. [Hsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
8. [SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
9. [The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
10. [Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
11. [Canonical and Kinase Activity-Independent Mechanisms for Extracellular Signal-Regulated Kinase 5 (ERK5) Nuclear Translocation Require Dissociation of Hsp90 from the ERK5-Cdc37 Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
12. [The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
13. [A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
14. [Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
15. [Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
16. [An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
17. [Hepatitis B Virus Polymerase Suppresses NF-κB Signaling by Inhibiting the Activity of IKKs via Interaction with Hsp90β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
18. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
19. [A Proteomic Investigation of Ligand-dependent HSP90 Complexes Reveals CHORDC1 as a Novel ADP-dependent HSP90-interacting Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
20. [A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
21. [Interaction proteome of human Hippo signaling: modular control of the co‐activator YAP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
22. [A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
23. [Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
24. [Interaction between Cdc37 and Cdk4 in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
25. [Comprehensive Proteomic Analysis of Human Par Protein Complexes Reveals an Interconnected Protein Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
26. [Hsp90 Regulates p50 Function during the Biogenesis of the Active Conformation of the Heme-regulated eIF2α Kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
27. [Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
28. [The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
29. [A physical and functional map of the human TNF-α/NF-κB signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
30. [HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
31. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
32. [Progressive degeneration of human neural stem cells caused by pathogenic LRRK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
33. [EXPRESSION OF CONCERN: HSP90 is required for TAK1 stability but not for its activation in the pro‐inflammatory signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
34. [14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
35. [Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
36. [Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
37. [Interactome mapping suggests new mechanistic details underlying Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
38. [Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
39. [Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
40. [A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
41. [Label‐free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
42. [Specific Binding of Tetratricopeptide Repeat Proteins to the C-terminal 12-kDa Domain of hsp90](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16543&geneProductId=UniProtKB:Q16543)
43. [Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16543&geneProductId=UniProtKB:Q16543)
44. [Specific Binding of Tetratricopeptide Repeat Proteins to the C-terminal 12-kDa Domain of hsp90](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
45. [Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
46. [Kinase Suppressor of Ras Forms a Multiprotein Signaling Complex and Modulates MEK Localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
47. [MHC class II‐associated proteins in B‐cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16543&geneProductId=UniProtKB:Q16543)
48. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16543&geneProductId=UniProtKB:Q16543)
49. [MHC class II‐associated proteins in B‐cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)
50. [Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16543)