# Cell division cycle 27

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130874](https://www.wikidata.org/wiki/Q21130874)  
**Source**: https://4ort.xyz/entity/cell-division-cycle-27


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P30260)
3. Q20641742
4. [Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
5. [Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
6. [Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
7. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
8. [A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
9. [The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
10. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
11. [ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
12. [Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
13. [Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
14. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
15. [Systematic analysis of human protein complexes identifies chromosome segregation proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
16. [The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
17. [Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
18. [Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
19. [Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
20. [Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
21. [Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
22. [SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
23. [Atomic structure of the APC/C and its mechanism of protein ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
24. [PP2A delays APC/C-dependent degradation of separase-associated but not free securin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
25. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
26. [C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
28. [CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
29. [Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
30. [APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
31. [Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260)
32. Ensembl Release 99