# Cell division cycle 20

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21422912](https://www.wikidata.org/wiki/Q21422912)  
**Source**: https://4ort.xyz/entity/cell-division-cycle-20-q21422912


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q12834)
3. Q20641742
4. [Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
5. [MAD2B is an inhibitor of the anaphase-promoting complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
6. [E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
7. [Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
8. [The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
9. [CDK5RAP2 is required for spindle checkpoint function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
10. [HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
11. [BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
12. [Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
13. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
14. [Determinants of conformational dimerization of Mad2 and its inhibition by p31comet](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
15. [A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
16. [The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
17. [Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
18. [ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
19. [Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
20. [The influence of catalysis on mad2 activation dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
21. [Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
22. [p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
23. [Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
24. [Systematic analysis of human protein complexes identifies chromosome segregation proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
25. [p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
26. [The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
27. [Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
28. [Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
29. [Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
30. [Aurora Kinase-A Inactivates DNA Damage-Induced Apoptosis and Spindle Assembly Checkpoint Response Functions of p73](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
31. [Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
32. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
33. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
34. [SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
35. [The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
36. [PP2A delays APC/C-dependent degradation of separase-associated but not free securin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
37. [Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
38. [Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
39. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
40. [A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
41. [Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834)
42. Ensembl Release 99
43. UMLS 2023