# CD8 antigen, alpha chain

> mammalian protein found in Mus musculus

**Wikidata**: [Q21494041](https://www.wikidata.org/wiki/Q21494041)  
**Source**: https://4ort.xyz/entity/cd8-antigen-alpha-chain


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P01731)
3. Q20641742
4. [Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731)
5. [Interactions between the amino‐terminal domain of p56lck and cytoplasmic domains of CD4 and CD8α in yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731)
6. [Lck availability during thymic selection determines the recognition specificity of the T cell repertoire](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731)
8. [Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731)
9. [FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
10. [Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
11. [GATA-3 is required for early T lineage progenitor development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
12. [Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin‐2‐deficient colitis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
13. [CDK6 kinase activity is required for thymocyte development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
14. [PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
15. [Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
16. [Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
17. [Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
18. [A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
19. [Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
20. [CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
21. [Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
22. [Accessory protein-like is essential for IL-18-mediated signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
23. [T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
24. [Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
25. [Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
26. [Glycosyltransferase function in core 2-type protein O glycosylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
27. [Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
28. [Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
29. [Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
30. [The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
31. [A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
32. [GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
33. [GATA-3 regulates the development and function of invariant NKT cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
34. [MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
35. [Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
36. [A novel mutation in CD83 results in the development of a unique population of CD4+ T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
37. [A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
38. [STAT5 is required for thymopoiesis in a development stage-specific manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
39. [Control of MHC restriction by TCR Valpha CDR1 and CDR2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
40. [Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
41. [The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
42. [CD8 is needed for development of cytotoxic T cells but not helper T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
43. [The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
44. [Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731)
45. [FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731)
46. [Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731)
47. [CD8 is needed for development of cytotoxic T cells but not helper T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731)
48. [Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731)
49. [Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731)
50. [Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731)