# CD4 molecule

> mammalian protein found in Homo sapiens

**Wikidata**: [Q412587](https://www.wikidata.org/wiki/Q412587)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/CD4)  
**Source**: https://4ort.xyz/entity/cd4-molecule


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P01730)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
7. [CD4 dimers constitute the functional component required for T cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
8. [Dimeric association and segmental variability in the structure of human CD4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
9. [A Zn2+ Ion Links the Cytoplasmic Tail of CD4 and the N-terminal Region of Lck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
10. [The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
11. [Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
12. [Energetics of the HIV gp120-CD4 binding reaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
13. [Cloning of ACP33 as a novel intracellular ligand of CD4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
14. [Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
15. [Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
16. [Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
17. [Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
18. [Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
19. [Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
20. [Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
21. [Structural definition of a conserved neutralization epitope on HIV-1 gp120](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
22. [Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
23. [Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
24. [A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
25. [Role of CD4 and CD8 in T cell activation and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
26. [CD4 Ligation on Human Blood Monocytes Triggers Macrophage Differentiation and Enhances HIV Infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
27. [Role of CD4 and CD8 in T cell activation and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01730&geneProductId=UniProtKB:P01730)
28. [CD4 Ligation on Human Blood Monocytes Triggers Macrophage Differentiation and Enhances HIV Infection](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01730&geneProductId=UniProtKB:P01730)
29. [Interaction between CD4 and class II MHC molecules mediates cell adhesion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01730&geneProductId=UniProtKB:P01730)
30. [Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01730&geneProductId=UniProtKB:P01730)
31. [The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01730&geneProductId=UniProtKB:P01730)
32. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01730&geneProductId=UniProtKB:P01730)
33. [Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
34. [Interaction of p56lck with CD4 in the yeast two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
35. [Interaction between CD4 and class II MHC molecules mediates cell adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
36. [Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
37. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
38. [The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
39. [Dimeric association and segmental variability in the structure of human CD4](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01730&geneProductId=UniProtKB:P01730)
40. [FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01730&geneProductId=UniProtKB:P01730)
41. [Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
42. [The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
43. [FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
44. [Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
45. [Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
46. [The level of CD4 surface protein influences T cell selection in the thymus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
47. [STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
48. [Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
49. [HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)
50. [CD4 raft association and signaling regulate molecular clustering at the immunological synapse site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730)