# CD28 molecule

> mammalian protein found in Homo sapiens

**Wikidata**: [Q1622348](https://www.wikidata.org/wiki/Q1622348)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/CD28)  
**Source**: https://4ort.xyz/entity/cd28-molecule


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P10747)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [CD28/B7 costimulation: a review](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
6. [Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
7. [Mechanism for down-regulation of CD28 by Nef.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
8. [Characterization of Lck-binding elements in the herpesviral regulatory Tip protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
9. [The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
10. [CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
11. [Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
12. [ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
13. [Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
14. [T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
15. [p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
16. [GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
17. [Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
18. [Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747)
21. [The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
22. [Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
24. [Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
25. [Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
26. [The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
27. [Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
28. [CD28/B7 system of T cell costimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
29. [CD28/B7 costimulation: a review](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747)
30. [Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747)
31. [Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747)
32. [Costimulation of CD4+ T cells via CD28 modulates human immunodeficiency virus type 1 infection and replication in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
33. [CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747)
34. Ensembl Release 99
35. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)