CCCTC-binding factor
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P18
  value: Protein CTCF PDB 1x6h.png
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P49711
additional property: PropertyValue
  property ID: P361
  value: Zinc finger C2H2 superfamily
additional property: PropertyValue
  property ID: P361
  value: Zinc finger C2H2-type, protein family
additional property: PropertyValue
  property ID: P486
  value: D000076246
additional property: PropertyValue
  property ID: P527
  value: Zinc finger C2H2-type
additional property: PropertyValue
  property ID: P637
  value: NP_001177951
additional property: PropertyValue
  property ID: P637
  value: NP_006556
additional property: PropertyValue
  property ID: P637
  value: XP_005255832
additional property: PropertyValue
  property ID: P638
  value: 1X6H
additional property: PropertyValue
  property ID: P638
  value: 2CT1
additional property: PropertyValue
  property ID: P672
  value: D12.776.157.687.157
additional property: PropertyValue
  property ID: P672
  value: D12.776.260.120
additional property: PropertyValue
  property ID: P672
  value: D12.776.660.235.050
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: transcription corepressor activity
additional property: PropertyValue
  property ID: P680
  value: DNA-binding transcription factor activity
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: chromosome
additional property: PropertyValue
  property ID: P681
  value: nucleolus
additional property: PropertyValue
  property ID: P682
  value: regulation of transcription, DNA-templated
additional property: PropertyValue
  property ID: P682
  value: regulation of gene expression, epigenetic
additional property: PropertyValue
  property ID: P682
  value: regulation of centromeric sister chromatid cohesion
additional property: PropertyValue
  property ID: P692
  value: PBB GE CTCF 202521 at fs.png
additional property: PropertyValue
  property ID: P702
  value: CTCF
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000264010
additional property: PropertyValue
  property ID: P705
  value: ENSP00000384707
additional property: PropertyValue
  property ID: P705
  value: ENSP00000494408
confidence:
  popularity graph score:
    score: 0.005
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 34
      unique citations norm: 0.013
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 34
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P18:
    value: Protein CTCF PDB 1x6h.png
    source count: 0
    confidence: 0.0
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P49711
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797357
    source count: 1
    confidence: 0.2
    value label: Zinc finger C2H2 superfamily
  P361:
    value: Q83164179
    source count: 1
    confidence: 0.2
    value label: Zinc finger C2H2-type, protein family
  P486:
    value: D000076246
    source count: 0
    confidence: 0.0
  P527:
    value: Q24785163
    source count: 1
    confidence: 0.2
    value label: Zinc finger C2H2-type
  P637:
    value: NP_001177951
    source count: 1
    confidence: 0.2
  P637:
    value: NP_006556
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005255832
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016878357
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001350845
    source count: 1
    confidence: 0.2
  P638:
    value: 1X6H
    source count: 1
    confidence: 0.2
  P638:
    value: 2CT1
    source count: 1
    confidence: 0.2
  P672:
    value: D12.776.157.687.157
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.260.120
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.660.235.050
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.660.720.157
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.664.235.050
    source count: 0
    confidence: 0.0
  P680:
    value: Q14633858
    source count: 2
    confidence: 0.4
    value label: DNA binding
  P680:
    value: Q14864664
    source count: 1
    confidence: 0.2
    value label: transcription corepressor activity
  P680:
    value: Q14817979
    source count: 2
    confidence: 0.4
    value label: DNA-binding transcription factor activity

value: Q14633865
source count: 1
confidence: 0.2
value label: zinc ion binding

value: Q13667380
source count: 1
confidence: 0.2
value label: metal ion binding

value: Q14817956
source count: 4
confidence: 0.8
value label: nucleoplasm

value: Q37748
source count: 1
confidence: 0.2
value label: chromosome

value: Q30869
source count: 1
confidence: 0.2
value label: nucleolus

value: Q14762596
source count: 3
confidence: 0.6
value label: chromosome, centromeric region

value: Q14862220
source count: 1
confidence: 0.2
value label: condensed chromosome

value: Q14633883
source count: 1
confidence: 0.2
value label: regulation of transcription, DNA-templated

value: Q4532193
source count: 1
confidence: 0.2
value label: regulation of gene expression, epigenetic

value: Q14902786
source count: 1
confidence: 0.2
value label: regulation of centromeric sister chromatid cohesion

value: Q5113927
source count: 1
confidence: 0.2
value label: chromosome segregation

value: Q14763010
source count: 1
confidence: 0.2
value label: transcription, DNA-templated

value: PBB GE CTCF 202521 at fs.png
source count: 0
confidence: 0.0

value: Q21163346
source count: 1
confidence: 0.2
value label: CTCF

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000264010
source count: 1
confidence: 0.2

value: ENSP00000384707
source count: 1
confidence: 0.2

value: ENSP00000494408
source count: 1
confidence: 0.2

value: ENSP00000494538
source count: 1
confidence: 0.2

value: ENSP00000493495
source count: 1
confidence: 0.2

value: http://purl.uniprot.org/uniprot/P49711
source count: 1
confidence: 0.2

value: C0669443
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
stated in qid: Q24316326
retrieved: 2019-04-08

source: A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers
stated in qid: Q24317542
retrieved: 2018-03-27

source: An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
stated in qid: Q24316326
retrieved: 2018-03-27

source: Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci
stated in qid: Q24293115
retrieved: 2019-04-08

source: Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2
stated in qid: Q24337403
retrieved: 2019-04-08

source: CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites
stated in qid: Q28115322
retrieved: 2019-04-08

source: JARID1B is a luminal lineage-driving oncogene in breast cancer
stated in qid: Q24299326
retrieved: 2019-04-08

source: The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting
stated in qid: Q34675046
retrieved: 2019-04-08

source: Vigilin interacts with CCCTC‐binding factor (CTCF) and is involved in CTCF‐dependent regulation of the imprinted genes Igf2 and H19
stated in qid: Q24294496
retrieved: 2019-04-08

source: A proteome-scale map of the human interactome network
stated in qid: Q24307146
retrieved: 2019-04-08

source: A census of human transcription factors: function, expression and evolution
stated in qid: Q29622841
retrieved: 2019-04-08

source: Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci
stated in qid: Q24293115
retrieved: 2018-03-27

source: A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers
stated in qid: Q24317542
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-03-27

source: CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin
stated in qid: Q24316093
retrieved: 2018-03-27

source: Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism
stated in qid: Q24313730
retrieved: 2018-03-27

source: Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism
stated in qid: Q24313730
retrieved: 2019-04-08

source: CTCF physically links cohesin to chromatin
stated in qid: Q24321344
retrieved: 2019-04-08

source: CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin
stated in qid: Q24316093
retrieved: 2019-04-08

source: CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic.
stated in qid: Q41073866
retrieved: 2019-04-08

source: The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein precursor promoter. Evidence for a role in transcriptional activation
stated in qid: Q24315790
retrieved: 2019-04-08

source: CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
stated in qid: Q24295238
retrieved: 2019-04-08

source: Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster
stated in qid: Q24309356
retrieved: 2019-04-08

source: DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation
stated in qid: Q24321761
retrieved: 2019-04-08

source: The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions
stated in qid: Q24312117
retrieved: 2018-03-27

source: The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions
stated in qid: Q24312117
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

wikidata id: Q5014546
domain: protein
level: standard
html url: https://4ort.xyz/entity/ccctc-binding-factor-q5014546
markdown url: https://4ort.xyz/entity/ccctc-binding-factor-q5014546.md
facts url summary: https://4ort.xyz/entity/ccctc-binding-factor-q5014546/facts.json
facts url standard: https://4ort.xyz/entity/ccctc-binding-factor-q5014546/facts.json
facts url full: https://4ort.xyz/entity/ccctc-binding-factor-q5014546/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-23T10:45:20.413672Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:08:01.642867+00:00Z