# CCAAT/enhancer binding protein (C/EBP), alpha

> mammalian protein found in Mus musculus

**Wikidata**: [Q21499243](https://www.wikidata.org/wiki/Q21499243)  
**Source**: https://4ort.xyz/entity/ccaat-enhancer-binding-protein-c-ebp-alpha


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P53566)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
5. [C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
6. [Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
7. [Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
8. [Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
9. [SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
10. [Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
11. [Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
12. [Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
13. [C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
14. [CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
15. [Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
16. [C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
17. [Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P53566&geneProductId=UniProtKB:P53566)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P53566&geneProductId=UniProtKB:P53566)
19. [C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters](http://www.ebi.ac.uk/QuickGO/annotations?protein=P53566&geneProductId=UniProtKB:P53566)
20. [Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
21. [Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
22. [Plasticity and expanding complexity of the hepatic transcription factor network during liver development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
23. [C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
24. [E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
25. [Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
26. [AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
27. [Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
28. [Suppression of C/EBP alpha expression in biliary cell differentiation from hepatoblasts during mouse liver development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
29. [Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
30. [T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P53566&geneProductId=UniProtKB:P53566)
31. [T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
32. [Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
33. [Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
34. [Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
35. [C/EBPalpha is required for lung maturation at birth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
36. [Regulation of Wnt signaling during adipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
37. [Essential requirement of CCAAT/enhancer binding proteins in embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
38. [Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
39. [Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
40. [Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
41. [Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
42. [Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
43. [Wdnm1-like, a new adipokine with a role in MMP-2 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
44. [Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
45. [Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
46. [NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
47. [The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
48. [Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
49. [Recycling of apolipoprotein E in mouse liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)
50. [The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566)