# cbl proto-oncogene

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21171522](https://www.wikidata.org/wiki/Q21171522)  
**Source**: https://4ort.xyz/entity/cbl-proto-oncogene


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
4. [The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22681&geneProductId=UniProtKB:P22681)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22681&geneProductId=UniProtKB:P22681)
6. [Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
7. [Stability of diluted solutions of peracetic acid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
8. [IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
9. [A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
10. [A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
11. [Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
12. [Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
13. [An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
14. [Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
15. [Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
16. [Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
17. [Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
18. [Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
19. [Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
20. [Threshold-controlled ubiquitination of the EGFR directs receptor fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
21. [Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
22. [A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
23. [Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
24. [Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
25. [Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
26. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
27. [c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
28. [SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
29. [PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
30. [Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
31. [Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
32. [Dab2 links CIN85 with clathrin-mediated receptor internalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
33. [Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
34. [A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
35. [Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
36. [Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
37. [A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
38. [Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
39. [Phospho-tyrosine dependent protein-protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
40. [The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
41. [Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
42. [The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
43. [Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
44. [Weak binding to E3 ubiquitin ligase c‐Cbl increases EGFRvA protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
45. [The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
46. [CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
47. [Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
48. [Charting the molecular network of the drug target Bcr-Abl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
49. [Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)
50. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681)