Cbl proto-oncogene B
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: orange
additional property: PropertyValue
  property ID: P637
  value: NP_001308715
additional property: PropertyValue
  property ID: P637
  value: NP_001308717
additional property: PropertyValue
  property ID: P637
  value: NP_001308718
additional property: PropertyValue
  property ID: P638
  value: 2AK5
additional property: PropertyValue
  property ID: P638
  value: 2BZ8
additional property: PropertyValue
  property ID: P638
  value: 2DO6
additional property: PropertyValue
  property ID: P680
  value: calcium ion binding
additional property: PropertyValue
  property ID: P680
  value: phosphotyrosine residue binding
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P682
  value: regulation of signaling
additional property: PropertyValue
  property ID: P682
  value: cell surface receptor signaling pathway
additional property: PropertyValue
  property ID: P682
  value: protein ubiquitination
additional property: PropertyValue
  property ID: P702
  value: CBLB
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000384816
additional property: PropertyValue
  property ID: P705
  value: ENSP00000377598
additional property: PropertyValue
  property ID: P705
  value: ENSP00000384938
confidence:
  popularity graph score:
    score: 0.004
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 29
      unique citations norm: 0.011
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 29
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q13191
    source count: 1
    confidence: 0.2
    value label: orange
  P637:
    value: NP_001308715
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001308717
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001308718
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001308719
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001308720
    source count: 1
    confidence: 0.2
  P638:
    value: 2AK5
    source count: 1
    confidence: 0.2
  P638:
    value: 2BZ8
    source count: 1
    confidence: 0.2
  P638:
    value: 2DO6
    source count: 1
    confidence: 0.2
  P638:
    value: 2J6F
    source count: 1
    confidence: 0.2
  P638:
    value: 2JNH
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633862
    source count: 1
    confidence: 0.2
    value label: calcium ion binding
  P680:
    value: Q14905186
    source count: 1
    confidence: 0.2
    value label: phosphotyrosine residue binding
  P680:
    value: Q13667380
    source count: 1
    confidence: 0.2
    value label: metal ion binding
  P680:
    value: Q167149
    source count: 20
    confidence: 1.0
    value label: protein binding
  P680:
    value: Q14860441
    source count: 1
    confidence: 0.2
    value label: ubiquitin-protein transferase activity
  P681:
    value: Q14817956
    source count: 1
    confidence: 0.2
    value label: nucleoplasm
  P681:
    value: Q79899
    source count: 1
    confidence: 0.2
    value label: cytoplasm
  P681:
    value: Q220599
    source count: 2
    confidence: 0.4
    value label: cytosol
  P681:
    value: Q29548
    source count: 2
    confidence: 0.4
    value label: plasma membrane
  P681:
    value: Q424178
    source count: 1
    confidence: 0.2
    value label: membrane raft
  P682:
    value: Q21117639
    source count: 1
    confidence: 0.2
    value label: regulation of signaling
  P682:
    value: Q14820580
    source count: 1
    confidence: 0.2
    value label: cell surface receptor signaling pathway
  P682:
    value: Q3547638
    source count: 1
    confidence: 0.2
    value label: protein ubiquitination

value: Q14906137
source count: 1
confidence: 0.2
value label: NLS-bearing protein import into nucleus

value: Q828130
source count: 1
confidence: 0.2
value label: signal transduction

value: Q17856033
source count: 1
confidence: 0.2
value label: CBLB

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000384816
source count: 1
confidence: 0.2

value: ENSP00000377598
source count: 1
confidence: 0.2

value: ENSP00000384938
source count: 1
confidence: 0.2

value: ENSP00000393906
source count: 1
confidence: 0.2

value: ENSP00000400949
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.
stated in qid: Q47296660
retrieved: 2019-04-08

source: A directed protein interaction network for investigating intracellular signal transduction
stated in qid: Q24337382
retrieved: 2019-04-08

source: LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
stated in qid: Q56967338
retrieved: 2019-04-08

source: A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
stated in qid: Q24294449
retrieved: 2019-04-08

source: Phospho-tyrosine dependent protein-protein interaction network
stated in qid: Q24324740
retrieved: 2019-04-08

source: Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
stated in qid: Q24307890
retrieved: 2019-04-08

source: Towards a proteome-scale map of the human protein–protein interaction network
stated in qid: Q21735930
retrieved: 2019-04-08

source: A proteome-scale map of the human interactome network
stated in qid: Q24307146
retrieved: 2019-04-08

source: Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation
stated in qid: Q22008757
retrieved: 2019-04-08

source: A human MAP kinase interactome
stated in qid: Q24302302
retrieved: 2019-04-08

source: Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain
stated in qid: Q24305567
retrieved: 2019-04-08

source: CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases
stated in qid: Q24304461
retrieved: 2019-04-08

source: Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications
stated in qid: Q24318683
retrieved: 2019-04-08

source: Pooled-matrix protein interaction screens using Barcode Fusion Genetics
stated in qid: Q28114947
retrieved: 2019-04-08

source: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
stated in qid: Q36940515
retrieved: 2019-04-08

source: Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*
stated in qid: Q24339595
retrieved: 2019-04-08

source: Ubiquitylation‐dependent downregulation of Nck regulates its functional activity
stated in qid: Q24304049
retrieved: 2019-04-08

source: Charting the molecular network of the drug target Bcr-Abl
stated in qid: Q24317707
retrieved: 2019-04-08

source: Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination
stated in qid: Q24321221
retrieved: 2019-04-08

source: CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery
stated in qid: Q24294662
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene
stated in qid: Q24322680
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-09-10

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-09-10

source: Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene
stated in qid: Q24322680
retrieved: 2018-06-05

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21108226
domain: protein
level: standard
html url: https://4ort.xyz/entity/cbl-proto-oncogene-b
markdown url: https://4ort.xyz/entity/cbl-proto-oncogene-b.md
facts url summary: https://4ort.xyz/entity/cbl-proto-oncogene-b/facts.json
facts url standard: https://4ort.xyz/entity/cbl-proto-oncogene-b/facts.json
facts url full: https://4ort.xyz/entity/cbl-proto-oncogene-b/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T04:40:18.527502Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:12:18.107337+00:00Z