# Cathepsin D

> mammalian protein found in Mus musculus

**Wikidata**: [Q21499226](https://www.wikidata.org/wiki/Q21499226)  
**Source**: https://4ort.xyz/entity/cathepsin-d


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P18242)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
5. [Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
6. [Lysosomal proteases are involved in generation of N-terminal huntingtin fragments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
7. [Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
9. [Regulated renin release from 3T3-L1 adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
10. [Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
11. [Regulated renin release from 3T3-L1 adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
13. [Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
14. [Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
15. [Identification and subcellular localization of a new cystinosin isoform](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
16. [Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
17. [II. Characterization and development of the regional- and cellular-specific abnormalities in the epididymis of mice with beta-hexosaminidase A deficiency](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
18. [Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
19. [Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
20. [Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
21. [Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
22. [Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
23. [Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
24. [Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
25. [Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
26. [Identification and subcellular localization of a new cystinosin isoform](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
27. [Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
28. [Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
29. [Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
30. [Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
31. [Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
32. [Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
33. [II. Characterization and development of the regional- and cellular-specific abnormalities in the epididymis of mice with beta-hexosaminidase A deficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
34. [Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
35. [Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
36. [Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242)
37. [Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242)
38. ensembl Release 106