# catabolite repression

> a process in which the presence of one nutrient source leads to a decrease in the frequency, rate, or extent of processes involved in the metabolism of other nutrient sources

**Wikidata**: [Q50350837](https://www.wikidata.org/wiki/Q50350837)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Catabolite_repression)  
**Source**: https://4ort.xyz/entity/catabolite-repression

## Summary

Catabolite repression is a biological process [1] that regulates gene expression in response to the availability of preferred carbon sources, such as glucose. When glucose is present, it inhibits the utilization of alternative carbon sources by suppressing the expression of genes involved in their metabolism [1]. This regulatory mechanism allows the organism to prioritize energy-efficient metabolic pathways [1]. Catabolite repression is observed in bacteria such as Escherichia coli and involves the cAMP-CRP complex as a key regulatory component [1].


## References

1. Gene Ontology release 2019-10-07
2. Gene Ontology release 2022-07-01
3. UMLS 2023
4. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)