# Caspase 9

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4216687](https://www.wikidata.org/wiki/Q4216687)  
**Source**: https://4ort.xyz/entity/caspase-9


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL197672)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P55211)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
6. [c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
7. [RETRACTED: Identification and characterization of GRIM-1, a cell-death-associated gene product](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
8. [A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
9. [The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
10. [CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
11. [Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
12. [Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
13. [HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
14. [Executioner caspase-3 and caspase-7 are functionally distinct proteases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
15. [An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
16. [Mechanism of XIAP-mediated inhibition of caspase-9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
17. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
18. [IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
19. [The dependence receptor DCC requires lipid raft localization for cell death signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
20. [ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
21. [Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
22. [Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
23. [The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
24. [Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
25. [Structure of an apoptosome-procaspase-9 CARD complex.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
26. [Livin, a novel inhibitor of apoptosis protein family member](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
27. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
28. [Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
29. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
30. [SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
31. [The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
32. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
33. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
34. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
35. [Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
36. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55211&geneProductId=UniProtKB:P55211)
37. [Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
38. [Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55211&geneProductId=UniProtKB:P55211)
39. [Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
40. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
41. [Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
42. [No death without life: vital functions of apoptotic effectors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
43. [c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55211&geneProductId=UniProtKB:P55211)
44. [ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55211&geneProductId=UniProtKB:P55211)
45. [BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55211&geneProductId=UniProtKB:P55211)
46. [ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
47. [BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55211)
48. Ensembl Release 99
49. KBpedia