# Caspase 8

> mammalian protein found in Mus musculus

**Wikidata**: [Q14911968](https://www.wikidata.org/wiki/Q14911968)  
**Source**: https://4ort.xyz/entity/caspase-8


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O89110)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O89110&geneProductId=UniProtKB:O89110)
6. [Caspase 8 inhibits programmed necrosis by processing CYLD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
7. [Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
8. [Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
9. [Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
10. [C/EBPβ Phosphorylation by RSK Creates a Functional XEXD Caspase Inhibitory Box Critical for Cell Survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
11. [Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
12. [Caveolin-1 mediates Fas–BID signaling in hyperoxia-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
13. [A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
14. [Palmitoylation is required for efficient Fas cell death signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
15. [Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
16. [NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
17. [Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
18. [The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
19. [TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
20. [FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
21. [Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
22. [Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O89110&geneProductId=UniProtKB:O89110)
23. [Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2](http://www.ebi.ac.uk/QuickGO/annotations?protein=O89110&geneProductId=UniProtKB:O89110)
24. [Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
26. [Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
27. [Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
28. [Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
29. [Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
30. [Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta](http://www.ebi.ac.uk/QuickGO/annotations?protein=O89110&geneProductId=UniProtKB:O89110)
31. [A mitochondrial protein compendium elucidates complex I disease biology](http://www.ebi.ac.uk/QuickGO/annotations?protein=O89110&geneProductId=UniProtKB:O89110)
32. [A mitochondrial protein compendium elucidates complex I disease biology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
33. [TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
34. [Survival function of the FADD-CASPASE-8-cFLIP(L) complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
35. [The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
36. [No death without life: vital functions of apoptotic effectors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
37. [Mechanisms of necroptosis in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
38. [No death without life: vital functions of apoptotic effectors](http://www.ebi.ac.uk/QuickGO/annotations?protein=O89110&geneProductId=UniProtKB:O89110)
39. [Caspase-8 serves both apoptotic and nonapoptotic roles](http://www.ebi.ac.uk/QuickGO/annotations?protein=O89110&geneProductId=UniProtKB:O89110)
40. [Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O89110&geneProductId=UniProtKB:O89110)
41. [Caspase-8 serves both apoptotic and nonapoptotic roles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
42. [Molecular cloning and characterization of mouse caspase‐8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
43. [Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89110)
44. ensembl Release 106
45. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)