# Caspase 8

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5049059](https://www.wikidata.org/wiki/Q5049059)  
**Source**: https://4ort.xyz/entity/caspase-8-q5049059


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL197672)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14790)
4. Q20641742
5. [Caspase-10 is an initiator caspase in death receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14790&geneProductId=UniProtKB:Q14790)
6. [Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
8. [Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14790&geneProductId=UniProtKB:Q14790)
9. [DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
10. [Calcium binding of ARC mediates regulation of caspase 8 and cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
11. [ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
12. [Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
13. [Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
14. [Casper is a FADD- and caspase-related inducer of apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
15. [PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
16. [FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
17. [Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
18. [Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
19. [Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
20. [Involvement of caspase 8 and c-FLIPL in the proangiogenic effects of the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
21. [Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
22. [PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
23. [Pick your poison: The Ripoptosome, a cell death platform regulating apoptosis and necroptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
24. [Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
25. [RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
26. [Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
27. [Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
28. [A type III effector antagonizes death receptor signalling during bacterial gut infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
29. [Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
30. [Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
31. [ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
32. [Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
33. [An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
34. [A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
35. [Yes and PI3K bind CD95 to signal invasion of glioblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
36. [Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
37. [Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
38. [The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
39. [Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
40. [Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
41. [Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
42. [A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
43. [Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
44. [The role of receptor internalization in CD95 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
45. [Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
46. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
47. [NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
48. [Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
49. [p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8–associated Protein in the Endoplasmic Reticulum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)
50. [Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790)