# Caspase 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5049057](https://www.wikidata.org/wiki/Q5049057)  
**Source**: https://4ort.xyz/entity/caspase-3


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL197672)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
5. [Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
6. [Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
7. [A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
8. [Casper is a FADD- and caspase-related inducer of apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
9. [Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
10. [Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
11. [Structural basis for the inhibition of caspase-3 by XIAP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
12. [Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
13. [S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
14. [A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
15. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
16. [Caspase-3-mediated cleavage of Akt: involvement of non-consensus sites and influence of phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
17. [Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
18. [Executioner caspase-3 and caspase-7 are functionally distinct proteases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
19. [Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
20. [Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
21. [The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42574&geneProductId=UniProtKB:P42574)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42574&geneProductId=UniProtKB:P42574)
23. [The human papillomavirus-16 E7 oncoprotein exerts antiapoptotic effects via its physical interaction with the actin-binding protein gelsolin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42574&geneProductId=UniProtKB:P42574)
24. [The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
25. [Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
26. [HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
27. [Huntingtin promotes cell survival by preventing Pak2 cleavage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
28. [Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
29. [The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42574&geneProductId=UniProtKB:P42574)
30. [Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
31. [The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
32. [The human papillomavirus-16 E7 oncoprotein exerts antiapoptotic effects via its physical interaction with the actin-binding protein gelsolin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
33. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
34. [No death without life: vital functions of apoptotic effectors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
35. [Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
36. [Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
37. [Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
38. [No death without life: vital functions of apoptotic effectors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42574&geneProductId=UniProtKB:P42574)
39. [Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42574&geneProductId=UniProtKB:P42574)
40. [Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
41. [Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
42. [Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
43. [Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
44. [CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42574&geneProductId=UniProtKB:P42574)
45. [A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42574&geneProductId=UniProtKB:P42574)
46. [CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
47. [A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42574)
48. Ensembl Release 99
49. Identifiers.org