# Caspase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5049051](https://www.wikidata.org/wiki/Q5049051)  
**Source**: https://4ort.xyz/entity/caspase-2-q5049051


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL197672)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P42575)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
6. [CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
7. [RAIDD is a new 'death' adaptor molecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
8. [Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
9. [ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
10. [Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
11. [The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
12. [Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
13. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
14. [Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
15. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
16. [Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
17. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575)
19. [Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
20. [PAX2 suppresses apoptosis in renal collecting duct cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
22. [No death without life: vital functions of apoptotic effectors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
23. [Expression of the Bcl-2 protein BAD promotes prostate cancer growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575)
24. [Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575)
25. Ensembl Release 99
26. Identifiers.org