# Caspase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5049052](https://www.wikidata.org/wiki/Q5049052)  
**Source**: https://4ort.xyz/entity/caspase-1


## References

1. UniProt
2. [Source](https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.22.36&UniProtAcc=P29466&OrganismID=2681)
3. [Source](https://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=3.4.22.36)
4. Q20641742
5. Freebase Data Dumps. 2013
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
7. [CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
8. [INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
9. [PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
10. [SERPINB1-mediated checkpoint of inflammatory caspase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
11. [Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
12. [The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
13. [Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
14. [Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
15. [Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
16. [Active caspase-1 is a regulator of unconventional protein secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
17. [Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
18. [Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
19. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
20. [Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
21. [Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
22. [Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
23. [A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
24. [Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
25. [The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
26. [NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
27. [NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
28. [The prodomain of caspase-1 enhances Fas-mediated apoptosis through facilitation of caspase-8 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
29. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29466&geneProductId=UniProtKB:P29466)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
31. [Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
32. [Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
33. [CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
34. [The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
35. [AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
36. [An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
37. [Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
38. [Expression of the Bcl-2 protein BAD promotes prostate cancer growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
39. [Molecular cloning of the interleukin-1 beta converting enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
40. [Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29466&geneProductId=UniProtKB:P29466)
41. [INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29466&geneProductId=UniProtKB:P29466)
42. [Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29466&geneProductId=UniProtKB:P29466)
43. [Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
44. [Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466)
45. Ensembl Release 99
46. Identifiers.org