# Casein kinase 2 alpha 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5048395](https://www.wikidata.org/wiki/Q5048395)  
**Source**: https://4ort.xyz/entity/casein-kinase-2-alpha-1-q5048395


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P68400)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
5. [Protein Kinase CK2 in Health and Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
6. [Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
7. [Isolation and characterization of human cDNA clones encoding the .alpha. and the .alpha.' subunits of casein kinase II](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400)
8. [The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400)
10. [Caspase‐2 primes cancer cells for TRAIL‐mediated apoptosis by processing procaspase‐8](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400)
11. [Functional Polymorphism of the CK2α Intronless Gene Plays Oncogenic Roles in Lung Cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400)
12. [CK2 Phosphorylation of the Armadillo Repeat Region of β-Catenin Potentiates Wnt Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400)
13. [CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400)
14. [Interactions of the HIV-1 Tat and RAP74 Proteins with the RNA Polymerase II CTD Phosphatase FCP1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400)
15. [Phosphorylation by Protein Kinase CK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
16. [Functional Polymorphism of the CK2α Intronless Gene Plays Oncogenic Roles in Lung Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
17. [The SUMO E3-ligase PIAS1 Regulates the Tumor Suppressor PML and Its Oncogenic Counterpart PML-RARA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
18. [Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine‐activated conditions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
19. [Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
20. [p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
21. [Phosphorylation of the WASP-VCA Domain Increases Its Affinity for the Arp2/3 Complex and Enhances Actin Polymerization by WASP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
22. [SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
23. [Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
24. [KIF5C: A new binding partner for protein kinase CK2 with a preference for the CK2α’ subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
25. [Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
26. [Protein Kinase CK2 Triggers Cytosolic Zinc Signaling Pathways by Phosphorylation of Zinc Channel ZIP7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
27. [An AUTS2–Polycomb complex activates gene expression in the CNS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
28. [Interactions of protein kinase CK2β subunit within the holoenzyme and with other proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
29. [A High-Density Map for Navigating the Human Polycomb Complexome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
30. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
31. [A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
32. [Dynamic Circadian Protein–Protein Interaction Networks Predict Temporal Organization of Cellular Functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
33. [A “Twist box” Code of p53 Inactivation: Twist box:p53 Interaction Promotes p53 Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
34. [Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
35. [LuTHy: a double‐readout bioluminescence‐based two‐hybrid technology for quantitative mapping of protein–protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
36. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
37. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
38. [Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
39. [The functional interactome landscape of the human histone deacetylase family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
40. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
41. [A Proteome-Scale Map of the Human Interactome Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
42. [Interaction Proteomics Analysis of Polycomb Proteins Defines Distinct PRC1 Complexes in Mammalian Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
43. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
44. [A CK2-Dependent Mechanism for Degradation of the PML Tumor Suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
45. [CK2 Is the Regulator of SIRT1 Substrate-Binding Affinity, Deacetylase Activity and Cellular Response to DNA-Damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
46. [A bead‐based approach for large‐scale identification of in vitro kinase substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
47. [The CK2 Kinase Stabilizes CLOCK and Represses Its Activity in the Drosophila Circadian Oscillator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
48. [Isolation and characterization of human cDNA clones encoding the .alpha. and the .alpha.' subunits of casein kinase II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
49. [The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)
50. [Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400)