# Casein kinase 1 epsilon

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5014192](https://www.wikidata.org/wiki/Q5014192)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/CSNK1E)  
**Source**: https://4ort.xyz/entity/casein-kinase-1-epsilon


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3948730)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49674)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
7. [Regulation of casein kinase I epsilon activity by Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
8. [Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
9. [Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49674&geneProductId=UniProtKB:P49674)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49674&geneProductId=UniProtKB:P49674)
11. [SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49674&geneProductId=UniProtKB:P49674)
12. [Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49674&geneProductId=UniProtKB:P49674)
13. [SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
14. [Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
15. [RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
16. [Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
17. [Modeling of a human circadian mutation yields insights into clock regulation by PER2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
18. [Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
19. [Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
20. [Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
21. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
22. [Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
23. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
24. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
25. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
26. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
27. [Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
28. [A directed protein interaction network for investigating intracellular signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
29. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
30. [Identification of a novel Wnt5a-CK1ε-Dvl2-Plk1-mediated primary cilia disassembly pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
31. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
32. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49674&geneProductId=UniProtKB:P49674)
33. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
34. [Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
35. [Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
36. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
37. [Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49674&geneProductId=UniProtKB:P49674)
38. [Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49674)
39. Ensembl Release 99
40. Identifiers.org