# Carnitine palmitoyltransferase 1A

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28561274](https://www.wikidata.org/wiki/Q28561274)  
**Source**: https://4ort.xyz/entity/carnitine-palmitoyltransferase-1a-q28561274


## References

1. UniProt
2. Q20641742
3. [Cloning and characterization of the promoter for the liver isoform of the rat carnitine palmitoyltransferase I (L-CPT I) gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
4. [Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
6. [An Environment-dependent Structural Switch Underlies the Regulation of Carnitine Palmitoyltransferase 1A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
7. [Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
8. [Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
9. [A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
10. [Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
11. [Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
12. [Pig liver carnitine palmitoyltransferase. Chimera studies show that both the N- and C-terminal regions of the enzyme are important for the unusual high malonyl-CoA sensitivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
13. [Identification by mutagenesis of conserved arginine and glutamate residues in the C-terminal domain of rat liver carnitine palmitoyltransferase I that are important for catalytic activity and malonyl-CoA sensitivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
15. [Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
16. [Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
17. [The extreme C terminus of rat liver carnitine palmitoyltransferase I is not involved in malonyl-CoA sensitivity but in initial protein folding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
18. [The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
19. [The N-terminal domain of rat liver carnitine palmitoyltransferase 1 contains an internal mitochondrial import signal and residues essential for folding of its C-terminal catalytic domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
20. [The liver isoform of carnitine palmitoyltransferase 1 is not targeted to the endoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
21. [Mitochondrial Carnitine Palmitoyltransferase 1a (CPT1a) Is Part of an Outer Membrane Fatty Acid Transfer Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
22. [Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
23. [Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
24. [A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
25. [The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
26. [Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32198)
27. ensembl Release 106