Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P27708
additional property: PropertyValue
  property ID: P361
  value: Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Carbamoyl-phosphate synthase, large subunit
additional property: PropertyValue
  property ID: P361
  value: Metal-dependent hydrolase
additional property: PropertyValue
  property ID: P527
  value: ATP-grasp fold
additional property: PropertyValue
  property ID: P527
  value: Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
additional property: PropertyValue
  property ID: P527
  value: Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
additional property: PropertyValue
  property ID: P637
  value: NP_001293008
additional property: PropertyValue
  property ID: P637
  value: NP_004332
additional property: PropertyValue
  property ID: P637
  value: XP_006712164
additional property: PropertyValue
  property ID: P638
  value: 4BY3
additional property: PropertyValue
  property ID: P638
  value: 4C6B
additional property: PropertyValue
  property ID: P638
  value: 4C6C
additional property: PropertyValue
  property ID: P680
  value: transferase activity
additional property: PropertyValue
  property ID: P680
  value: protein kinase activity
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: nuclear matrix
additional property: PropertyValue
  property ID: P682
  value: cellular amino acid metabolic process
additional property: PropertyValue
  property ID: P682
  value: pyrimidine nucleoside biosynthetic process
additional property: PropertyValue
  property ID: P682
  value: glutamine metabolic process
additional property: PropertyValue
  property ID: P702
  value: CAD
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000264705
additional property: PropertyValue
  property ID: P705
  value: ENSP00000384510
additional property: PropertyValue
  property ID: P705
  value: ENSP00000388740
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 18
      unique citations norm: 0.007
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 18
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P27708
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797586
    source count: 1
    confidence: 0.2
    value label: Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily
  P361:
    value: Q24772854
    source count: 1
    confidence: 0.2
    value label: Carbamoyl-phosphate synthase, large subunit
  P361:
    value: Q24768309
    source count: 1
    confidence: 0.2
    value label: Metal-dependent hydrolase
  P361:
    value: Q24783234
    source count: 1
    confidence: 0.2
    value label: Metal-dependent hydrolase, composite domain superfamily
  P361:
    value: Q24781040
    source count: 1
    confidence: 0.2
    value label: Class I glutamine amidotransferase-like
  P527:
    value: Q24777344
    source count: 1
    confidence: 0.2
    value label: ATP-grasp fold
  P527:
    value: Q24719538
    source count: 1
    confidence: 0.2
    value label: Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
  P527:
    value: Q24727253
    source count: 1
    confidence: 0.2
    value label: Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
  P527:
    value: Q24777809
    source count: 1
    confidence: 0.2
    value label: Amidohydrolase-related
  P527:
    value: Q24773693
    source count: 1
    confidence: 0.2
    value label: Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
  P637:
    value: NP_001293008
    source count: 1
    confidence: 0.2
  P637:
    value: NP_004332
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006712164
    source count: 1
    confidence: 0.2
  P637:
    value: XP_024308899
    source count: 1
    confidence: 0.2
  P638:
    value: 4BY3
    source count: 1
    confidence: 0.2
  P638:
    value: 4C6B
    source count: 1
    confidence: 0.2
  P638:
    value: 4C6C
    source count: 1
    confidence: 0.2
  P638:
    value: 4C6D
    source count: 1
    confidence: 0.2
  P638:
    value: 4C6E
    source count: 1
    confidence: 0.2
  P680:
    value: Q14840131
    source count: 1
    confidence: 0.2
    value label: transferase activity

value: Q14820641
source count: 1
confidence: 0.2
value label: protein kinase activity

value: Q14860365
source count: 1
confidence: 0.2
value label: nucleotide binding

value: Q14851770
source count: 1
confidence: 0.2
value label: amino acid binding

value: Q21121201
source count: 1
confidence: 0.2
value label: aspartate binding

value: Q79899
source count: 1
confidence: 0.2
value label: cytoplasm

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q906755
source count: 1
confidence: 0.2
value label: nuclear matrix

value: Q14817956
source count: 1
confidence: 0.2
value label: nucleoplasm

value: Q903634
source count: 1
confidence: 0.2
value label: extracellular exosome

value: Q14859896
source count: 1
confidence: 0.2
value label: cellular amino acid metabolic process

value: Q14859870
source count: 1
confidence: 0.2
value label: pyrimidine nucleoside biosynthetic process

value: Q14878312
source count: 2
confidence: 0.4
value label: glutamine metabolic process

value: Q14914558
source count: 1
confidence: 0.2
value label: nitrogen compound metabolic process

value: Q14859867
source count: 3
confidence: 0.6
value label: 'de novo' pyrimidine nucleobase biosynthetic process

value: Q17855283
source count: 1
confidence: 0.2
value label: CAD

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000264705
source count: 1
confidence: 0.2

value: ENSP00000384510
source count: 1
confidence: 0.2

value: ENSP00000388740
source count: 1
confidence: 0.2

value: ENSP00000405416
source count: 1
confidence: 0.2

value: ENSP00000414742
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD
stated in qid: Q24312222
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2017-10-17

source: Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD
stated in qid: Q24312222
retrieved: 2017-10-17

source: The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD
stated in qid: Q24301815
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-01-01

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Defining the membrane proteome of NK cells
stated in qid: Q24323157
retrieved: 2017-10-17

source: Adenovirus Preterminal Protein Binds to the CAD Enzyme at Active Sites of Viral DNA Replication on the Nuclear Matrix
stated in qid: Q24321076
retrieved: 2019-04-08

source: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
stated in qid: Q24311780
retrieved: 2017-10-17

source: Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD
stated in qid: Q24301937
retrieved: 2019-04-08

source: Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD
stated in qid: Q24301937
retrieved: 2017-10-17

source: Defining the membrane proteome of NK cells
stated in qid: Q24323157
retrieved: 2019-04-08

source: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
stated in qid: Q24311780
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21121202
domain: protein
level: standard
html url: https://4ort.xyz/entity/carbamoyl-phosphate-synthetase-2-aspartate-transcarbamylase-and-dihydroorotase
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facts url full: https://4ort.xyz/entity/carbamoyl-phosphate-synthetase-2-aspartate-transcarbamylase-and-dihydroorotase/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-12T22:34:29.844751Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:47:25.717321+00:00Z