# calcium sensing receptor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q417801](https://www.wikidata.org/wiki/Q417801)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Calcium-sensing_receptor)  
**Source**: https://4ort.xyz/entity/calcium-sensing-receptor


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1201284)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545184)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL292376)
6. Q20641742
7. Freebase Data Dumps. 2013
8. [The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
10. [Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
11. [Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
12. [Structural mechanism of ligand activation in human calcium-sensing receptor.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
13. [Structural mechanism of ligand activation in human calcium-sensing receptor.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
14. [Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
16. [Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
19. [Identification and functional analysis of a novel CaSR mutation in a family with familial hypocalciuric hypercalcemia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
20. [Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
21. [CASR gene activating mutations in two families with autosomal dominant hypocalcemia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
22. [Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
23. [Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
24. [A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
25. [Novel activating mutation of human calcium-sensing receptor in a family with autosomal dominant hypocalcaemia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
26. [Neonatal severe hyperparathyroidism associated with a novel de novo heterozygous R551K inactivating mutation and a heterozygous A986S polymorphism of the calcium-sensing receptor gene.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
27. [Novel activating mutation of human calcium-sensing receptor in a family with autosomal dominant hypocalcaemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
28. [Neonatal severe hyperparathyroidism associated with a novel de novo heterozygous R551K inactivating mutation and a heterozygous A986S polymorphism of the calcium-sensing receptor gene.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
29. [Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
30. [Identification and functional analysis of a novel CaSR mutation in a family with familial hypocalciuric hypercalcemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
31. [A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
32. [CASR gene activating mutations in two families with autosomal dominant hypocalcemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
33. [Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
34. [A homozygous inactivating calcium-sensing receptor mutation, Pro339Thr, is associated with isolated primary hyperparathyroidism: correlation between location of mutations and severity of hypercalcaemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
35. [Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
36. [Clustered inactivating mutations and benign polymorphisms of the calcium receptor gene in familial benign hypocalciuric hypercalcemia suggest receptor functional domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
37. [A novel mutation in calcium-sensing receptor gene associated to hypercalcemia and hypercalciuria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
38. [Two novel mutations of the calcium-sensing receptor gene affecting the same amino acid position lead to opposite phenotypes and reveal the importance of p.N802 on receptor activity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
39. [Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
40. [A novel mutation in the calcium-sensing receptor in a French family with familial hypocalciuric hypercalcaemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
41. [Loss-of-Function and Gain-of-Function Mutations of Calcium-Sensing Receptor: Functional Analysis and the Effect of Allosteric Modulators NPS R-568 and NPS 2143](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180)
42. [Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180)
43. Ensembl Release 99
44. Identifiers.org
45. Quora
46. Transporter Classification database
47. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)