# Calcium channel, voltage-dependent, L type, alpha 1S subunit

> mammalian protein found in Mus musculus

**Wikidata**: [Q21497155](https://www.wikidata.org/wiki/Q21497155)  
**Source**: https://4ort.xyz/entity/calcium-channel-voltage-dependent-l-type-alpha-1s-subunit


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q02789)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02789&geneProductId=UniProtKB:Q02789)
6. [Ca2+ sparks in embryonic mouse skeletal muscle selectively deficient in dihydropyridine receptor alpha1S or beta1a subunits](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02789&geneProductId=UniProtKB:Q02789)
7. [Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02789&geneProductId=UniProtKB:Q02789)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
9. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
10. [Ca2+ sparks in embryonic mouse skeletal muscle selectively deficient in dihydropyridine receptor alpha1S or beta1a subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
11. [Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
12. [The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02789&geneProductId=UniProtKB:Q02789)
13. [Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02789&geneProductId=UniProtKB:Q02789)
14. [Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02789&geneProductId=UniProtKB:Q02789)
15. [The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
16. [A novel isoform of delta-sarcoglycan is localized at the sarcoplasmic reticulum of mouse skeletal muscle.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
17. [Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
18. [Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
19. [Effects of the muscular dysgenesis gene on developmental stability in the mouse mandible](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
20. [Electrical properties of normal and dysgenib mouse skeletal muscle in culture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
21. [Neurons induce contractions in myotubes containing only muscular dysgenic nuclei](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
22. [Relationship of genotype and in vitro contractility in mdg/mdg in equilibrium +/+ "mosaic" myotubes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
23. [Restoration of normal ultrastructure after expression of the alpha 1 subunit of the L-type Ca2+ channel in dysgenic myotubes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
24. [A lethal mutation in mice eliminates the slow calcium current in skeletal muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
25. [Elimination by necrosis, not apoptosis, of embryonic extraocular muscles in the muscular dysgenesis mutant of the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
26. [Fine structure of mutant (muscular dysgenesis) embryonic mouse muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
27. [Distribution and quantification of ACh receptors and innervation in diaphragm muscle of normal and mdg mouse embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
28. [Extensive nerve overgrowth and paucity of the tailed asymmetric form (16 S) of acetylcholinesterase in the developing skeletal neuromuscular system of the dysgenic (mdg/mdg) mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
29. [Muscle and nerve in muscular dysgenesis in the mouse at birth: Sprouting and multiple innervation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
30. [Tissue culture study of murine muscular dysgenesis: role of spontaneous action potential generation in the regulation of muscle maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
31. [Regulation of myogenesis in paralyzed muscles in the mouse mutants peroneal muscular atrophy and muscular dysgenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
32. [M-calpain levels increase during fusion of myoblasts in the mutant muscular dysgenesis (mdg) mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
33. [DEVELOPMENTAL GENETICS OF A LETHAL MUTATION, MUSCULAR DYSGENESIS (MDG), IN THE MOUSE. I. GENETIC ANALYSIS AND GROSS MORPHOLOGY](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
34. [DEVELOPMENTAL GENETICS OF A LETHAL MUTATION, MUSCULAR DYSGENESIS (MDG), IN THE MOUSE. II. DEVELOPMENTAL ANALYSIS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
35. [Endogenous cardiac Ca2+ channels do not overcome the E‐C coupling defect in immortalized dysgenic muscle cells: evidence for a missing link](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
36. [Disease expression in +-/+- ----mdg/mdg mouse chimeras: evidence for an extramuscular component in the pathogenesis of both dysgenic abnormal diaphragm innervation and skeletal muscle 16 S acetylcholinesterase deficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
37. [A single nucleotide deletion in the skeletal muscle-specific calcium channel transcript of muscular dysgenesis (mdg) mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
38. [Modification of mitochondrial metabolism in fibroblasts from mice with a skeletal muscle mutation (muscular dysgenesis). Evidence of embryonic communication between myoblasts and fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02789&geneProductId=UniProtKB:Q02789)
39. [Barium currents in developing skeletal muscle cells of normal and mutant mice foetuses with 'muscular dysgenesis'](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02789&geneProductId=UniProtKB:Q02789)
40. [Barium currents in developing skeletal muscle cells of normal and mutant mice foetuses with 'muscular dysgenesis'](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
41. [Modification of mitochondrial metabolism in fibroblasts from mice with a skeletal muscle mutation (muscular dysgenesis). Evidence of embryonic communication between myoblasts and fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02789)
42. ensembl Release 106