# C9orf72-SMCR8 complex subunit

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21102398](https://www.wikidata.org/wiki/Q21102398)  
**Source**: https://4ort.xyz/entity/c9orf72-smcr8-complex-subunit


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q96LT7)
3. Q20641742
4. [C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
5. [C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
6. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
7. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
8. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
9. [Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
10. [Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LT7&geneProductId=UniProtKB:Q96LT7)
13. [C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LT7&geneProductId=UniProtKB:Q96LT7)
14. [C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
15. [The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
16. [C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
17. [Isoform‐specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LT7&geneProductId=UniProtKB:Q96LT7)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
19. [The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LT7)
20. [Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LT7&geneProductId=UniProtKB:Q96LT7)
21. [C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LT7&geneProductId=UniProtKB:Q96LT7)
22. [C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LT7&geneProductId=UniProtKB:Q96LT7)
23. Ensembl Release 99