C-X3-C motif chemokine ligand 1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P78423
additional property: PropertyValue
  property ID: P361
  value: Chemokine interleukin-8-like superfamily
additional property: PropertyValue
  property ID: P361
  value: fractalkine
additional property: PropertyValue
  property ID: P361
  value: Chemokine interleukin-8-like domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Chemokine interleukin-8-like domain
additional property: PropertyValue
  property ID: P527
  value: CX3C chemokine domain
additional property: PropertyValue
  property ID: P637
  value: NP_001291321
additional property: PropertyValue
  property ID: P637
  value: NP_002987
additional property: PropertyValue
  property ID: P638
  value: 1B2T
additional property: PropertyValue
  property ID: P638
  value: 1F2L
additional property: PropertyValue
  property ID: P638
  value: 3ONA
additional property: PropertyValue
  property ID: P646
  value: /m/027dtfq
additional property: PropertyValue
  property ID: P680
  value: cytokine activity
additional property: PropertyValue
  property ID: P680
  value: chemokine activity
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: G protein-coupled receptor signaling pathway
additional property: PropertyValue
  property ID: P682
  value: defense response
additional property: PropertyValue
  property ID: P682
  value: positive regulation of inflammatory response
additional property: PropertyValue
  property ID: P692
  value: PBB GE CX3CL1 823 at fs.png
additional property: PropertyValue
  property ID: P702
  value: CX3CL1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000006053
additional property: PropertyValue
  property ID: P705
  value: ENSP00000456830
additional property: PropertyValue
  property ID: P705
  value: ENSP00000457996
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 14
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 14
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P78423
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797185
    source count: 1
    confidence: 0.2
    value label: Chemokine interleukin-8-like superfamily
  P361:
    value: Q24784114
    source count: 1
    confidence: 0.2
    value label: fractalkine
  P361:
    value: Q83139055
    source count: 1
    confidence: 0.2
    value label: Chemokine interleukin-8-like domain, protein family
  P361:
    value: Q83167378
    source count: 1
    confidence: 0.2
    value label: CX3C chemokine domain, protein family
  P527:
    value: Q24767885
    source count: 1
    confidence: 0.2
    value label: Chemokine interleukin-8-like domain
  P527:
    value: Q28544160
    source count: 1
    confidence: 0.2
    value label: CX3C chemokine domain
  P637:
    value: NP_001291321
    source count: 1
    confidence: 0.2
  P637:
    value: NP_002987
    source count: 1
    confidence: 0.2
  P638:
    value: 1B2T
    source count: 1
    confidence: 0.2
  P638:
    value: 1F2L
    source count: 1
    confidence: 0.2
  P638:
    value: 3ONA
    source count: 1
    confidence: 0.2
  P638:
    value: 4XT1
    source count: 1
    confidence: 0.2
  P638:
    value: 4XT3
    source count: 1
    confidence: 0.2
  P646:
    value: /m/027dtfq
    source count: 1
    confidence: 0.2
  P680:
    value: Q14862699
    source count: 1
    confidence: 0.2
    value label: cytokine activity
  P680:
    value: Q14875871
    source count: 4
    confidence: 0.8
    value label: chemokine activity
  P680:
    value: Q167149
    source count: 4
    confidence: 0.8
    value label: protein binding
  P680:
    value: Q14907786
    source count: 1
    confidence: 0.2
    value label: CCR chemokine receptor binding
  P680:
    value: Q14819233
    source count: 1
    confidence: 0.2
    value label: signaling receptor binding
  P681:
    value: Q14327652
    source count: 3
    confidence: 0.6
    value label: integral component of membrane

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q29548
source count: 2
confidence: 0.4
value label: plasma membrane

value: Q14645596
source count: 3
confidence: 0.6
value label: extracellular region

value: Q189094
source count: 2
confidence: 0.4
value label: cell surface

value: Q14758909
source count: 1
confidence: 0.2
value label: G protein-coupled receptor signaling pathway

value: Q14820936
source count: 1
confidence: 0.2
value label: defense response

value: Q14859639
source count: 1
confidence: 0.2
value label: positive regulation of inflammatory response

value: Q14860501
source count: 1
confidence: 0.2
value label: monocyte chemotaxis

value: Q14863107
source count: 3
confidence: 0.6
value label: cytokine-mediated signaling pathway

value: PBB GE CX3CL1 823 at fs.png
source count: 0
confidence: 0.0

value: Q14907780
source count: 1
confidence: 0.2
value label: CX3CL1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000006053
source count: 1
confidence: 0.2

value: ENSP00000456830
source count: 1
confidence: 0.2

value: ENSP00000457996
source count: 1
confidence: 0.2

value: ENSP00000464114
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
stated in qid: Q24300435
retrieved: 2018-01-01

source: Structural Basis of Chemokine Sequestration by CrmD, a Poxvirus-Encoded Tumor Necrosis Factor Receptor
stated in qid: Q24321225
retrieved: 2018-01-01

source: Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1
stated in qid: Q22001501
retrieved: 2018-01-01

source: Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor
stated in qid: Q35652476
retrieved: 2018-01-01

source: Integrins αvβ3 and α4β1 Act as Coreceptors for Fractalkine, and the Integrin-Binding Defective Mutant of Fractalkine Is an Antagonist of CX3CR1
stated in qid: Q28119172
retrieved: 2018-01-01

source: The Chemokine Fractalkine Can Activate Integrins without CX3CR1 through Direct Binding to a Ligand-Binding Site Distinct from the Classical RGD-Binding Site
stated in qid: Q31160040
retrieved: 2018-01-01

source: Fractalkine Is Expressed by Smooth Muscle Cells in Response to IFN-γ and TNF-α and Is Modulated by Metalloproteinase Activity
stated in qid: Q24292098
retrieved: 2018-01-01

source: MicroRNA-29b regulates migration in oral squamous cell carcinoma and its clinical significance
stated in qid: Q29347543
retrieved: 2018-01-01

source: InterPro Release 71.0
stated in qid: Q58943792

source: Freebase Data Dumps
stated in qid: Q15241312
pub year: 2013

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q2743450
domain: protein
level: standard
html url: https://4ort.xyz/entity/c-x3-c-motif-chemokine-ligand-1-q2743450
markdown url: https://4ort.xyz/entity/c-x3-c-motif-chemokine-ligand-1-q2743450.md
facts url summary: https://4ort.xyz/entity/c-x3-c-motif-chemokine-ligand-1-q2743450/facts.json
facts url standard: https://4ort.xyz/entity/c-x3-c-motif-chemokine-ligand-1-q2743450/facts.json
facts url full: https://4ort.xyz/entity/c-x3-c-motif-chemokine-ligand-1-q2743450/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-12T11:50:37.381831Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:34:58.412611+00:00Z