# C-X-C motif chemokine receptor 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q415718](https://www.wikidata.org/wiki/Q415718)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/CXCR4)  
**Source**: https://4ort.xyz/entity/c-x-c-motif-chemokine-receptor-4


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL518924)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P61073)
5. Q20641742
6. Freebase Data Dumps. 2013
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
8. [Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073)
10. [beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
11. [Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
12. [RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
13. [Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
14. [Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
15. [Actin-binding protein drebrin regulates HIV-1-triggered actin polymerization and viral infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
16. [Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
17. [CXCR4-CCR5: a couple modulating T cell functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
18. [Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
19. [A functional heteromeric MIF receptor formed by CD74 and CXCR4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
20. [Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
21. [Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
22. [F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
23. [CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1α/CXCR4 axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
24. [The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
25. [Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
26. [Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
27. [CXC Chemokine Receptor 4 Is a Cell Surface Receptor for Extracellular Ubiquitin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
28. [Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
30. [Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
31. [Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
32. [Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
33. [CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
34. [CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
35. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073)
36. [The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein–coupled receptor CXCR4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
37. [Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
38. [Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
39. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
40. [Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
41. [Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073)
42. [Use of chemokine receptors by poxviruses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
43. [The multiple personalities of the chemokine receptor CCR7 in dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
44. [Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073)
45. [HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
46. [Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
47. [Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
48. [The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
49. [Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)
50. [Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073)