# C-X-C motif chemokine ligand 8

> mammalian protein found in Homo sapiens

**Wikidata**: [Q421859](https://www.wikidata.org/wiki/Q421859)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Interleukin_8)  
**Source**: https://4ort.xyz/entity/c-x-c-motif-chemokine-ligand-8


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P10145)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
6. [Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
7. [TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
8. [HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
9. [Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) Proteins Function as the Human IL-8-Binding Effectors and Contribute to Pathogen Entry into Human Neutrophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
10. [Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
11. [Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
12. [Structure and Functional Expression of a Human Interleukin-8 Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
13. [An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145)
14. [Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145)
16. [Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145)
17. [An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
18. [Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
19. [Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
21. [Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
22. [IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
23. [Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
24. [Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
25. [Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
26. [CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
27. [Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
28. [Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
29. [Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
30. [Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
31. [Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145)
32. [Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145)
33. [A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
34. [A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145)
35. [TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
36. [Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
37. [CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
38. [Ca(2+) signalling by recombinant human CXCR2 chemokine receptors is potentiated by P2Y nucleotide receptors in HEK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145)
39. [Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145)
40. [Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145)
41. [ChEBI](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:138181)
42. Ensembl Release 99
43. Identifiers.org
44. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)