# C-C motif chemokine receptor 5

> mammalian protein found in Homo sapiens

**Wikidata**: [Q418404](https://www.wikidata.org/wiki/Q418404)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/CCR5)  
**Source**: https://4ort.xyz/entity/c-c-motif-chemokine-receptor-5


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1668019)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1951914)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P51681)
6. Q20641742
7. Freebase Data Dumps. 2013
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
9. [Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
10. [Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681)
12. [Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
13. [CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
14. [Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
15. [NMR mapping of RANTES surfaces interacting with CCR5 using linked extracellular domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
16. [CXCR4-CCR5: a couple modulating T cell functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
17. [Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
18. [Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
19. [Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
20. [Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
21. [CCR5 is a receptor for Staphylococcus aureus leukotoxin ED.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
22. [Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
23. [Molecular cloning and functional expression of a new human CC-chemokine receptor gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681)
24. [Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681)
25. [The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681)
26. [Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
27. [Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681)
28. [Molecular cloning and functional expression of a new human CC-chemokine receptor gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
29. [Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
30. [The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
31. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
32. [Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
33. [Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
34. [Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681)
35. [Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
36. [Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681)
37. [Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
38. [Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
39. [Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
40. [p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
41. [Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681)
42. [The multiple personalities of the chemokine receptor CCR7 in dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
43. [Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681)
44. [Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681)
45. Ensembl Release 99
46. Identifiers.org
47. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)