C-C motif chemokine receptor 5
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: O08556
additional property: PropertyValue
  property ID: P361
  value: CC chemokine receptor 5
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P361
  value: GPCR, rhodopsin-like, 7TM, protein family
additional property: PropertyValue
  property ID: P527
  value: GPCR, rhodopsin-like, 7TM
additional property: PropertyValue
  property ID: P637
  value: NP_446412
additional property: PropertyValue
  property ID: P680
  value: G protein-coupled receptor activity
additional property: PropertyValue
  property ID: P680
  value: chemokine receptor activity
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: endosome
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: inflammatory response to antigenic stimulus
additional property: PropertyValue
  property ID: P682
  value: chemotaxis
additional property: PropertyValue
  property ID: P682
  value: inflammatory response
additional property: PropertyValue
  property ID: P702
  value: Ccr5
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000073121
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 25
      unique citations norm: 0.01
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 25
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: O08556
    source count: 1
    confidence: 0.2
  P361:
    value: Q24738418
    source count: 1
    confidence: 0.2
    value label: CC chemokine receptor 5
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83162561
    source count: 1
    confidence: 0.2
    value label: GPCR, rhodopsin-like, 7TM, protein family
  P527:
    value: Q24781798
    source count: 1
    confidence: 0.2
    value label: GPCR, rhodopsin-like, 7TM
  P637:
    value: NP_446412
    source count: 1
    confidence: 0.2
  P680:
    value: Q14859545
    source count: 2
    confidence: 0.4
    value label: G protein-coupled receptor activity
  P680:
    value: Q14864357
    source count: 1
    confidence: 0.2
    value label: chemokine receptor activity
  P680:
    value: Q167149
    source count: 2
    confidence: 0.4
    value label: protein binding
  P680:
    value: Q14865164
    source count: 4
    confidence: 0.8
    value label: C-C chemokine receptor activity
  P680:
    value: Q14817984
    source count: 1
    confidence: 0.2
    value label: protein kinase binding
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P681:
    value: Q824237
    source count: 1
    confidence: 0.2
    value label: endosome
  P681:
    value: Q29548
    source count: 1
    confidence: 0.2
    value label: plasma membrane
  P681:
    value: Q14633850
    source count: 2
    confidence: 0.4
    value label: external side of plasma membrane
  P681:
    value: Q189094
    source count: 1
    confidence: 0.2
    value label: cell surface
  P682:
    value: Q14907247
    source count: 1
    confidence: 0.2
    value label: inflammatory response to antigenic stimulus
  P682:
    value: Q658145
    source count: 2
    confidence: 0.4
    value label: chemotaxis
  P682:
    value: Q14819849
    source count: 3
    confidence: 0.6
    value label: inflammatory response
  P682:
    value: Q1612119
    source count: 2
    confidence: 0.4
    value label: immune response
  P682:
    value: Q828130
    source count: 1
    confidence: 0.2
    value label: signal transduction
  P702:
    value: Q24380942
    source count: 1
    confidence: 0.2
    value label: Ccr5
  P703:
    value: Q184224
    source count: 1
    confidence: 0.2
    value label: brown rat
  P705:
    value: ENSRNOP00000073121
    source count: 1
    confidence: 0.2
citations:
  source: GOA
  stated in qid: Q28018111
  retrieved: 2019-02-14

source: Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis
stated in qid: Q28582484
retrieved: 2019-02-14

source: Chemokines released from astrocytes promote chemokine receptor 5-mediated neuronal cell differentiation
stated in qid: Q28578976
retrieved: 2019-02-14

source: Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies
stated in qid: Q28572119
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: Chemokine receptor expression in rat adjuvant-induced arthritis
stated in qid: Q28575108
retrieved: 2019-02-14

source: Localization and expression of CCR3 and CCR5 by interleukin-1 beta in the RIN-5AH insulin-producing model system: a protective mechanism involving down-regulation of chemokine receptors
stated in qid: Q28573981
retrieved: 2019-02-14

source: Crucial role of CCL3/MIP-1alpha in the recurrence of autoimmune anterior uveitis induced with myelin basic protein in Lewis rats
stated in qid: Q28582858
retrieved: 2019-02-14

source: Chemokine ligand (CCL)-3 promotes an integrated febrile response when injected within pre-optic area (POA) of rats and induces calcium signaling in cells of POA microcultures but not TNF-α or IL-6 synthesis
stated in qid: Q28582241
retrieved: 2019-02-14

source: Induction of RANTES and CCR5 through NF-kappaB activation via MAPK pathway in aged rat gingival tissues
stated in qid: Q28575306
retrieved: 2019-02-14

source: Caffeic acid phenethyl ester modifies the Th1/Th2 balance in ileal mucosa after gamma-irradiation in the rat by modulating the cytokine pattern
stated in qid: Q28567815
retrieved: 2019-02-14

source: Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage
stated in qid: Q28576511
retrieved: 2019-02-14

source: Angiotensin II-induced mononuclear leukocyte interactions with arteriolar and venular endothelium are mediated by the release of different CC chemokines
stated in qid: Q28564355
retrieved: 2019-02-14

source: Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-associated sensory neuropathy
stated in qid: Q28565160
retrieved: 2019-02-14

source: Microglial expression of chemokine receptor CCR5 during rat forebrain development and after perinatal hypoxia-ischemia
stated in qid: Q28570658
retrieved: 2019-02-14

source: Differential sensitivities of pyrogenic chemokine fevers to CC chemokine receptor 5 antibodies
stated in qid: Q28571321
retrieved: 2019-02-14

source: Th1- and Th2-related chemokine and chemokine receptor expression on the ocular surface in endotoxin-induced uveitis
stated in qid: Q28576706
retrieved: 2019-02-14

source: HIV-1 viral envelope glycoprotein gp120 triggers an inflammatory response in cultured rat astrocytes and regulates the functional expression of P-glycoprotein
stated in qid: Q28582939
retrieved: 2019-02-14

source: Cloning of rat HIV-1-chemokine coreceptor CKR5 from microglia and upregulation of its mRNA in ischemic and endotoxinemic rat brain
stated in qid: Q28569361
retrieved: 2019-02-14

source: Culture and differentiation of preadipocytes in two-dimensional and three-dimensional in vitro systems
stated in qid: Q28571344
retrieved: 2019-02-14

source: M- and T-tropic HIVs promote apoptosis in rat neurons
stated in qid: Q28572213
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q28561632
domain: protein
level: standard
html url: https://4ort.xyz/entity/c-c-motif-chemokine-receptor-5-q28561632
markdown url: https://4ort.xyz/entity/c-c-motif-chemokine-receptor-5-q28561632.md
facts url summary: https://4ort.xyz/entity/c-c-motif-chemokine-receptor-5-q28561632/facts.json
facts url standard: https://4ort.xyz/entity/c-c-motif-chemokine-receptor-5-q28561632/facts.json
facts url full: https://4ort.xyz/entity/c-c-motif-chemokine-receptor-5-q28561632/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-05T05:13:12.284645Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:27:14.058956+00:00Z