# C-C motif chemokine ligand 5

> mammalian protein found in Homo sapiens

**Wikidata**: [Q3492926](https://www.wikidata.org/wiki/Q3492926)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/CCL5)  
**Source**: https://4ort.xyz/entity/c-c-motif-chemokine-ligand-5


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P13501)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
7. [Aggregation of RANTES is responsible for its inflammatory properties. Characterization of nonaggregating, noninflammatory RANTES mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
8. [Platelets Secrete an Eosinophil-Chemotactic Cytokine which is a Member of the C-C-Chemokine Family](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13501&geneProductId=UniProtKB:P13501)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13501&geneProductId=UniProtKB:P13501)
10. [Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13501&geneProductId=UniProtKB:P13501)
11. [RANTES and MIP-1α Activate Stats in T Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
12. [Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
13. [Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
14. [Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
15. [Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
16. [LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
17. [Functional and biochemical analysis of the cloned Duffy antigen: identity with the red blood cell chemokine receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
18. [RANTES and MCP-3 antagonists bind multiple chemokine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
19. [NMR mapping of RANTES surfaces interacting with CCR5 using linked extracellular domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
20. [Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
21. [Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
22. [Oligomeric Structure of the Chemokine CCL5/RANTES from NMR, MS, and SAXS Data](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
23. [The X-ray structure of RANTES: heparin-derived disaccharides allows the rational design of chemokine inhibitors.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
24. [Platelets Secrete an Eosinophil-Chemotactic Cytokine which is a Member of the C-C-Chemokine Family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
25. [Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
27. [Chemokines regulate T cell adherence to recombinant adhesion molecules and extracellular matrix proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
28. [Bronchial Epithelium–Derived IL-8 and RANTES Increased Bronchial Smooth Muscle Cell Migration and Proliferation by Krüppel-like Factor 5 in Areca Nut–Mediated Airway Remodeling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
29. [RANTES activation of phospholipase D in Jurkat T cells: requirement of GTP-binding proteins ARF and RhoA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
30. [TNF-alpha inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
31. [TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
32. [Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13501&geneProductId=UniProtKB:P13501)
33. [CCR5 usage by CCL5 induces a selective leukocyte recruitment in human skin xenografts in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
34. [The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
35. [CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13501&geneProductId=UniProtKB:P13501)
36. [RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13501&geneProductId=UniProtKB:P13501)
37. [CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
38. [Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
39. [Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
40. [XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
41. [Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13501&geneProductId=UniProtKB:P13501)
42. [In vitro correlates of HIV-2-mediated HIV-1 protection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
43. [Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
44. [Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
45. [Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
46. [CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
47. [CCR5 usage by CCL5 induces a selective leukocyte recruitment in human skin xenografts in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13501&geneProductId=UniProtKB:P13501)
48. [RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13501&geneProductId=UniProtKB:P13501)
49. [RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)
50. [RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13501)