# C-C motif chemokine ligand 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2587862](https://www.wikidata.org/wiki/Q2587862)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/CCL2)  
**Source**: https://4ort.xyz/entity/c-c-motif-chemokine-ligand-2


## References

1. UniProt
2. Q20641742
3. Freebase Data Dumps. 2013
4. [Role of the first extracellular loop in the functional activation of CCR2. The first extracellular loop contains distinct domains necessary for both agonist binding and transmembrane signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
5. [Bacterial superantigens induce down-modulation of CC chemokine responsiveness in human monocytes via an alternative chemokine ligand-independent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
7. [Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
8. [Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
9. [Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
10. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
11. [An oxidized lipid-peroxisome proliferator-activated receptor gamma-chemokine pathway in the regulation of macrophage-vascular smooth muscle cell adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
12. [Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
13. [Toxoplasma gondii induces the secretion of monocyte chemotactic protein-1 in human fibroblasts, in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13500&geneProductId=UniProtKB:P13500)
15. [MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
16. [Permissive factors for HIV-1 infection of macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
17. [Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
18. [The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
19. [Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
20. [Generation, characterization and biological activity of CCL2 (MCP-1/JE) and CCL12 (MCP-5) specific antibodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
21. [Cloning, Expression, and Chromosomal Mapping of a Novel Human CC-Chemokine Receptor (CCR10) That Displays High-Affinity Binding for MCP-1 and MCP-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
22. [Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
23. [Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13500&geneProductId=UniProtKB:P13500)
24. [Role of the first extracellular loop in the functional activation of CCR2. The first extracellular loop contains distinct domains necessary for both agonist binding and transmembrane signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13500&geneProductId=UniProtKB:P13500)
25. [Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13500&geneProductId=UniProtKB:P13500)
26. [Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
27. [Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
28. [Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
29. [Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
30. [Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
31. [Functional expression of CCR2 by human fetal astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
32. [Human galectin-3 is a novel chemoattractant for monocytes and macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
33. [Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
34. [Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13500&geneProductId=UniProtKB:P13500)
35. [MicroRNA-495 regulates the proliferation and apoptosis of human umbilical vein endothelial cells by targeting chemokine CCL2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13500)
36. Ensembl Release 99
37. UMLS 2023
38. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)