# C-abl oncogene 1, non-receptor tyrosine kinase

> mammalian protein found in Mus musculus

**Wikidata**: [Q14874000](https://www.wikidata.org/wiki/Q14874000)  
**Source**: https://4ort.xyz/entity/c-abl-oncogene-1-non-receptor-tyrosine-kinase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P00520)
3. Q20641742
4. [Identification of a ten-amino acid proline-rich SH3 binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
6. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P00520)
7. [Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P00520)
8. [Functional interaction between DNA-PK and c-Abl in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
9. [Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P00520)
10. [Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P00520)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
12. [Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
13. [c-Abl-Mediated Tyrosine Phosphorylation of the T-bet DNA-Binding Domain Regulates CD4+ T-Cell Differentiation and Allergic Lung Inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
14. [Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
15. [Characterization of a novel member of the DOK family that binds and modulates Abl signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
16. [c-Abl phosphorylates Dok1 to promote filopodia during cell spreading](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
17. [Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
18. [Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
19. [Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
20. [Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
21. [Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
22. [c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
23. [Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
24. [Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
25. [Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
26. [Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
27. [SHP-2 is a novel target of Abl kinases during cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
28. [Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
29. [c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
30. [c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
31. [c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
32. [Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
33. [Abl Family Kinases Regulate FcγR-Mediated Phagocytosis in Murine Macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
34. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00520&geneProductId=UniProtKB:P00520)
35. [Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
36. [Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
37. [Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
38. [EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
39. [NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
40. [Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
41. [The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
42. [c-Abl-deficient mice exhibit reduced numbers of peritoneal B-1 cells and defects in BCR-induced B cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
43. [The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
44. [Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1–mediated survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
45. [Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
46. [The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
47. [Essential roles for the Abl and Arg tyrosine kinases in neurulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
48. [NF-kappaB activity is constitutively elevated in c-Abl null fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
49. [Defective T cell development and function in the absence of Abelson kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)
50. [Abl family kinases regulate endothelial barrier function in vitro and in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520)