# Bruton's tyrosine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q423572](https://www.wikidata.org/wiki/Q423572)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Bruton's_tyrosine_kinase)  
**Source**: https://4ort.xyz/entity/bruton-s-tyrosine-kinase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL4650485)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3707348)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3301625)
6. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q06187)
7. Q20641742
8. Freebase Data Dumps. 2013
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06187&geneProductId=UniProtKB:Q06187)
11. [Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
12. [Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
13. [Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06187&geneProductId=UniProtKB:Q06187)
14. [B cell signaling. Introduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
15. [Regulated association of protein kinase B/Akt with breast tumor kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
16. [The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
17. [Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
18. [Identification and Characterization of a Novel SH3-Domain Binding Protein, Sab, Which Preferentially Associates with Bruton's Tyrosine Kinase (Btk)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
19. [Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
20. [Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
21. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
22. [Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
23. [BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
24. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
25. [Btk-dependent regulation of phosphoinositide synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
26. [Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
27. [Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
29. [An exon-skipping mutation in the btk gene of a patient with X-linked agammaglobulinemia and isolated growth hormone deficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
30. [Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
31. [BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06187)
32. Ensembl Release 99
33. Identifiers.org
34. UMLS 2023
35. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)