# Bromodomain containing 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21100441](https://www.wikidata.org/wiki/Q21100441)  
**Source**: https://4ort.xyz/entity/bromodomain-containing-4


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [BioGRID](https://thebiogrid.org/news/227)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O60885)
5. Q20641742
6. [Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
7. [Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
8. [Selective inhibition of BET bromodomains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
9. [Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
10. [Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
11. [Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
12. [Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
13. [ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
14. [The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
15. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
16. [Large scale genotype comparison of human papillomavirus E2-host interaction networks provides new insights for e2 molecular functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
17. [Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
18. [Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
19. [Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
20. [Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
21. [Search for cellular partners of human papillomavirus type 16 E2 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
22. [A Y2H-seq approach defines the human protein methyltransferase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
23. [BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60885&geneProductId=UniProtKB:O60885)
24. [BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
25. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60885&geneProductId=UniProtKB:O60885)
27. [The bromodomain protein Brd4 insulates chromatin from DNA damage signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60885&geneProductId=UniProtKB:O60885)
28. [A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
29. [Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60885)
30. Ensembl Release 99
31. UMLS 2023