# Bridging integrator 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115486](https://www.wikidata.org/wiki/Q21115486)  
**Source**: https://4ort.xyz/entity/bridging-integrator-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O00499)
3. Q20641742
4. [Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
5. [Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
6. [Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
7. [The myotubularin-amphiphysin 2 complex in membrane tubulation and centronuclear myopathies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
8. [The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
9. [Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
10. [Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
11. [Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
12. [Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
13. [Hepatitis C virus infection protein network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
14. [The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
15. [Bin2, a functionally nonredundant member of the BAR adaptor gene family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
16. [The membrane-tubulating potential of amphiphysin 2/BIN1 is dependent on the microtubule-binding cytoplasmic linker protein 170 (CLIP-170)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
17. [Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00499&geneProductId=UniProtKB:O00499)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00499&geneProductId=UniProtKB:O00499)
19. [BIN1 regulates BACE1 intracellular trafficking and amyloid-β production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
21. [Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
22. [Roles of tau protein in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
23. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
24. [The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00499&geneProductId=UniProtKB:O00499)
25. [Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
26. [Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
27. [Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin1, a novel Myc interacting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
28. [BIN1 is a novel MYC-interacting protein with features of a tumour suppressor](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00499&geneProductId=UniProtKB:O00499)
29. [Mutations in BIN1 associated with centronuclear myopathy disrupt membrane remodeling by affecting protein density and oligomerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00499)
30. Ensembl Release 99
31. UMLS 2023