# Breast cancer 1, early onset

> mammalian protein found in Mus musculus

**Wikidata**: [Q14862232](https://www.wikidata.org/wiki/Q14862232)  
**Source**: https://4ort.xyz/entity/breast-cancer-1-early-onset


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P48754)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
5. [Genomic instability in mice lacking histone H2AX](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
7. [BRCA1 supports XIST RNA concentration on the inactive X chromosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48754&geneProductId=UniProtKB:P48754)
9. [Brca1 and Brca2 protein expression patterns in different tissues of murine origin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
10. [FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
11. [Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
12. [VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
13. [Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
14. [HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
15. [Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
16. [Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
17. [p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
18. [Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
19. [Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
20. [BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
21. [A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
22. [BRCA1 affects global DNA methylation through regulation of DNMT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
23. [Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48754&geneProductId=UniProtKB:P48754)
24. [BRCA1 affects global DNA methylation through regulation of DNMT1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48754&geneProductId=UniProtKB:P48754)
25. [BRCA1 is an essential regulator of heart function and survival following myocardial infarction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
26. [BRCA1 supports XIST RNA concentration on the inactive X chromosome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48754&geneProductId=UniProtKB:P48754)
27. [BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
28. [Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48754)
29. ensembl Release 106