# BRCA2 DNA repair associated

> mammalian protein found in Homo sapiens

**Wikidata**: [Q421651](https://www.wikidata.org/wiki/Q421651)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/BRCA2)  
**Source**: https://4ort.xyz/entity/brca2-dna-repair-associated


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P51587)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
6. [The BRCA2 is a histone acetyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
7. [BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
8. [BRCA2 associates with acetyltransferase activity when bound to P/CAF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
9. [Highlight: BRCA1 and BRCA2 proteins in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
10. [Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
11. [BRCA2 suppresses cell proliferation via stabilizing MAGE-D1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
12. [Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
13. [Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
14. [BRCA2 and homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
15. [PALB2 regulates recombinational repair through chromatin association and oligomerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
16. [Purified human BRCA2 stimulates RAD51-mediated recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
17. [FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
18. [A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell–based assay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
19. [WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
20. [Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
21. [Analysis of albumin-associated peptides and proteins from ovarian cancer patients](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
22. [Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
23. [CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
24. [Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
25. [Resistance to therapy caused by intragenic deletion in BRCA2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
26. [Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
27. [Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
28. [Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
29. [Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
30. [ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
31. [The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
32. [Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
33. [PALB2 is an integral component of the BRCA complex required for homologous recombination repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
34. [A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
35. [Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
36. [Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
37. [Analysis of PALB2/FANCN-associated breast cancer families](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
38. [A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
39. [A mechanism for the suppression of homologous recombination in G1 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
40. [DSS1 is required for the stability of BRCA2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
41. [The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
42. [APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
43. [Structural basis for recruitment of BRCA2 by PALB2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
44. [Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
45. [Insights into DNA recombination from the structure of a RAD51-BRCA2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
46. [FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
47. [Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
48. [Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
49. [The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)
50. [Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587)